Postdoktor to study new biomarkers of von Willebrand disease - Under tillsättning eller tillsatt, ej sökbar

Vill du bidra till en bättre hälsa för alla?

The postdoctoral position is placed in the Clinical Chemistry & Coagulation group at MMK with associate professor Jovan Antovic MD, PhD as a project leader. The research group consists of two basic research postdocs, two clinical postdocs, two PhD students and one biomedical scientist. The main focuses of the group are global hemostasis assays and hemostasis disorders-hemophilia, von Willebrand disease and thrombophilia. Read more:clinical-chemistry-and-blood-coagulation

Din roll

The project associated with the postdoctoral position is related to the Von Willebrand disease (VWD), the most common inherited bleeding disorder with a population prevalence of 1% and symptomatic prevalence of 1 in 1000. It is caused by quantitative or qualitative abnormalities of von Willebrand factor (VWF).  Despite the increasing knowledge on VWF and VWD, the diagnosis still remains difficult, particularly in milder cases of bleeding, because the disease presents with a wide spectrum of clinical phenotypes that overlap with normal subjects. Multifactorial nature of VWD clearly shows that there are undiscovered disease modifiers and physiological determinants that should be investigated. The purpose of the project is to define the physiological and proteomic landscape that underlies the complexity of clinical phenotypes, seen in patients with von Willebrand disease. One of the interesting physiological determinants are microparticles, a microvesicles with both anticoagulant and procoagulant abilities. One of the possible causes of the observed variation in the clinical phenotype of patients with von Willebrand disease could be the fluctuating structure and properties of the fibrin clot. The goals of the project are

1. To examine secondary hemostasis events using the global hemostasis assays
2. To examine the content fibrin clot architecture and fibrin network structure by confocal and scanning electron microscopy
3. To examine fibrin-clot bound microparticles using confocal and scanning electron microscopy
4. To examine fibrin-bound proteins in fibrin clots using proteomics

Vem är du?

Qualified to be employed as a postdoc is one who has obtained a doctorate or has equivalent scientific competence.

We are interested in candidates with strong background in hemostasis and basic research. Applicants are required to have completed a PhD degree in a field related to the position such as molecular biology, biochemistry or biomedicine. Experience in working with microparticles and epidemiological studies are a merit. Further requirements are:

• Documented experience in hemostasis research
• Documented experience in fluorescent microscopy and image analysis
• Knowledge regarding the proteomic methods is a strong advantage
• Basic knowledge of global hemostasis assays will be considered a distinct advantage
• Documented ability to write scientific articles and a track record of publications in international refereed journals is required
• Excellent communication skills and the ability to work both independently and in collaboration with colleagues in very diverse fields, including clinical staff, and the ability to document work.
• Documented experience in supervision of students and/or PhD students is required.
• Fluency in English is a requirement, knowledge of Swedish is not necessary but will be considered advantageous

Personal suitability is an important criterion.

Vad erbjuder vi?

En kreativ och inspirerande miljö fylld av kompetens och nyfikenhet. Karolinska Institutet är ett av världens ledande medicinska universitet. Vår vision är att driva utvecklingen av kunskap om livet och verka för en bättre hälsa för alla. Här bedriver vi framgångsrik medicinsk forskning och har det största utbudet av medicinska utbildningar i Sverige. Som universitet är Karolinska Institutet även en statlig myndighet. Det innebär att du får goda förmåner genom vårt kollektivavtal, generös semester och en bra tjänstepension. Du får träna fritt i våra moderna friskvårdsanläggningar och får ersättning för läkarvård.

Placering: Solna

Ansökan

Ansökan ska bestå av följande handlingar, skrivna på engelska eller svenska:

• En komplett CV inkluderande disputationsdatum, avhandlingens titel, tidigare akademiska befattningar, akademisk titel, nuvarande befattning, akademiska utmärkelser samt kommittéarbete
• En komplett publikationslista
• En sammanfattning av nuvarande arbete (maximalt en sida)

Ansökan ska göras via rekryteringssystemet Varbi. 

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