Do you want to contribute to better health for all?

The postdoctoral position is placed in the Clinical Chemistry & Coagulation group at MMK with associate professor Jovan Antovic MD, PhD as a project leader. The research group consists of two basic research postdocs, two clinical postdocs, two PhD students and one biomedical scientist. The main focuses of the group are global hemostasis assays and hemostasis disorders-hemophilia, von Willebrand disease and thrombophilia. Read more:clinical-chemistry-and-blood-coagulation

Your mission

The project associated with the postdoctoral position is related to the Von Willebrand disease (VWD), the most common inherited bleeding disorder with a population prevalence of 1% and symptomatic prevalence of 1 in 1000. It is caused by quantitative or qualitative abnormalities of von Willebrand factor (VWF).  Despite the increasing knowledge on VWF and VWD, the diagnosis still remains difficult, particularly in milder cases of bleeding, because the disease presents with a wide spectrum of clinical phenotypes that overlap with normal subjects. Multifactorial nature of VWD clearly shows that there are undiscovered disease modifiers and physiological determinants that should be investigated. The purpose of the project is to define the physiological and proteomic landscape that underlies the complexity of clinical phenotypes, seen in patients with von Willebrand disease. One of the interesting physiological determinants are microparticles, a microvesicles with both anticoagulant and procoagulant abilities. One of the possible causes of the observed variation in the clinical phenotype of patients with von Willebrand disease could be the fluctuating structure and properties of the fibrin clot. The goals of the project are

  1. To examine secondary hemostasis events using the global hemostasis assays
  2. To examine the content fibrin clot architecture and fibrin network structure by confocal and scanning electron microscopy
  3. To examine fibrin-clot bound microparticles using confocal and scanning electron microscopy
  4. To examine fibrin-bound proteins in fibrin clots using proteomics

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. We are interested in candidates with strong background in hemostasis and basic research. Applicants are required to have completed a PhD degree in a field related to the position such as molecular biology, biochemistry or biomedicine. Experience in working with microparticles and epidemiological studies are a merit. Further requirements are:

  • Documented experience in hemostasis research
  • Documented experience in fluorescent microscopy and image analysis
  • Knowledge regarding the proteomic methods is a strong advantage
  • Basic knowledge of global hemostasis assays will be considered a distinct advantage
  • Documented ability to write scientific articles and a track record of publications in international refereed journals is required
  • Excellent communication skills and the ability to work both independently and in collaboration with colleagues in very diverse fields, including clinical staff, and the ability to document work.
  • Documented experience in supervision of students and/or PhD students is required.
  • Fluency in English is a requirement, knowledge of Swedish is not necessary but will be considered advantageous.

Personal suitability is an important criterion.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.


Location:  Solna 

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
 

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position
Contract type Full time
Number of positions 1
Full-time equivalent 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-5309/2019
Contact
  • Jovan Antovic/Forskargruppsledare, jovan.antovic@ki.se
Union representative
  • Virpi Töhönen, virpi.tohonen@ki.se
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75
  • Elisabeth Noren-Krog, OFR, elisabeth.noren-krog@ki.se
Published 21.Oct.2019
Last application date 14.Nov.2019 11:59 PM CET

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