The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, bioorganic chemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

Aging is one of the main risk factors for morbidity and mortality. Thus, pharmaceuticals that would target aging and slow down its progression bear great potential to improve human health and quality of life. Unfortunately, identifying such pharmaceuticals is difficult; but we are in the unique position to have developed a strategy that can identify such pharmaceuticals by the combination of high-throughput transcriptomic screening and machine-learning based data analysis. We now use this strategy to identify new aging-preventive compounds and validate them in in vitro and in vivo models of aging.

Your mission

We are looking for a Postdoc to join our research group. The group is headed by Christian Riedel and studies the molecular mechanisms that regulate age-related decline, combining insights from model organisms and humans. The focus of this fully funded position is to use and refine our newly developed human cell-culture based screening platform that by means of high-throughput transcriptomics and machine-learning-based analysis can identify new aging-preventive candidate compounds (See also Janssens et al., Cell Reports 2019, for a proof-of-concept study demonstrating the potential of our screening approach.). Newly identified candidate compounds shall then be analyzed by aging-related assays in cell culture and eventually mice. The postdoc will establish these validation assays and put them to use.

This is a collaboration project with the pharmaceutical company AstraZeneca and with sequencing experts at Karolinska Institutet. Further, the Postdoc will synergize with aging biologists and bioinformaticians from the Riedel lab and be part of a larger aging-focused research environment at our department, which also contains the labs of Martin Bergö and Maria Eriksson.

We are looking for a talented and highly motivated scientist with a doctoral degree and strong background in Molecular Biology, Cell Biology, Genetics, and/or Biochemistry. Good expertise in mammalian cell culture techniques is a requirement. A background in the biology of aging or in high-content screening methodology is appreciated but not essential. Applicants are expected to work independently but as part of an enthusiastic team and to be proficient in English. They shall play a leading role in experimental design, experimentation, analysis, and the presentation/publication of their results. 
The applicant will be encouraged to apply for competitive national and international postdoctoral fellowships and career grants and will receive support in those endeavors.

Your profile

To be qualified for employment as a Postdoctoral Researcher, you need to hold a PhD or doctoral degree at the time of application. However, researchers who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) starting date of the employment. This must be confirmed by the applicant's main supervisor, department head, or equivalent.

What do we offer?

A fully funded position for one year with the possibility of extension.

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.


Location:
Department of Biosciences and Nutrition, Neo building, Flemingsberg


Links: https://ki.se/en/bionut/department-of-biosciences-and-nutrition

           https://ki.se/en/bionut/christian-riedel-group

           http://riedellab.org/

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Application

An employment application must contain the following documents in English:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

You are welcome to apply at the latest by 16 October 2020.

The application has to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100 %
City Huddinge
County Stockholms län
Country Sweden
Reference number STÖD 2-3380/2020
Contact
  • Christian Riedel, +46-73-670 7008
  • Thomas Tinglöv, Head of Administration, +46-8-524 835 49
Union representative
  • Henry Wölling, SEKO, +46-8-524 840 80
  • Anders Lindholm, OFR, +46-8-524 810 12
  • Chandrashekar Bangalore Revanna , SACO, +46-73-083 98 85
Published 15.Sep.2020
Last application date 16.Oct.2020 11:59 PM CET

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