Karolinska Institutet,

The Department of Dental Medicine at Campus Flemingsberg focuses on the education of dentists and
dental hygienists. In addition, we perform research, dental specialization training and provide patient
care by specialist dentists.
Karolinska Institutet and the rest of Scandinavia have been world leaders in dentistry for decades.

Location
Margaret Sällberg Chen’s research group - Unit for Oral Diagnostics and Surgery

Duties
This postdoctoral research position is immediately available in the research group of Dr. Margaret Sällberg Chen. The position is for a scientist with background in disease conditions associated with dysfunctionality in host immunity and/or oral-gut microbiota. The candidate will be part of a research team that aims at understanding new mechanistic insights of in patients diagnosed with conditions related to pancreatic and liver cancer development. The work comprises monitoring of immunological, microbiome dynamics using clinical speciments, including the latest 3-D microfluidic models to understand the impact of microbiota in cancer including immunotherapy. Disease-specific markers will be investigated to develop diagnostic methods and individualized therapeutic strategies to improve human health. 

The post doctoral fellows to be recruited to the project will be part of a multidisciplinary team and are expected to take active part in collaborative efforts, in line with the overall aims of this project. The studies will require methodological skills - from handling of human biopsy/biofluid to cell sorting, and/or molecular biology assays related to metagenomics sequencing analysis. The project is suitable for highly motivated researchers in molecular life sciences, especially those who have already knowledge of NGS bioinformatics workflow and resources. 

Some of our recent studies:
Gaiser et al. Enrichment of Oral Microbiota in Early Cystic Precursors to Invasive Pancreatic Cancer. GUT. Accepted for publication.

Sobkowiak M, et al. Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17. Eur J Immunol, 2019 Jan;49(1):133-143.

Sarene Koh, et al. Engineering non-cytolytic T cells activating the APOBEC3 innate antiviral pathway. Gastroenterology. 2018 Mar 14. pii: S0016-5085(18)30321-4.

Balasiddaiah et al. Hepatitis C Virus-Specific T Cell Receptor mRNA-engineered Human T Cells: Impact of Antigen-Specificity on Functional Properties. J of Virol. 2017 Feb 22. JV Spotlight Editor´s choice

Qualifications
To qualify the applicant must hold a doctoral degree or a foreign qualification equivalent to a doctorate. A PhD in life science or medical science on molecular biology, microbiology, or infection immunology is preferred. In addition to methodological skills, proven interactive experiences with clinical and bioinformatics collaborators is also required. He or she should have excellent organisational competence, writing and presentation skills. Applicants must have excellent communication skills in English.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An employment application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Reference number 2-1206/2019
Contact
  • Margaret Sällberg Chen, Research Group Leader , +46-8-524 881 25
  • Charlotte Wikhagen, Human Resource Officer, 08-52488046
Union representative
  • Nikolaos Christidis, SACO, 070-037 49 67
  • Marianne Johansson, OFR, 08-524 881 11
Published 22.Feb.2019
Last application date 15.Mar.2019 11:59 PM CET

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