Postdoctoral Researcher in antiviral cellular immunity

Do you want to contribute to top quality medical research?

Within our research group you will find a unique opportunity to work closely together with cutting edge researchers in the intersection between infectious diseases, antiviral treatment, antiviral immunity, and viral pathogenesis. We offer an engaging and international research environment where you may contribute to high quality research on an internationally competitive level.

Our research group has a strong focus on pathogenesis, immunity, treatment, prophylaxis, and cure of HIV infection. More recently, we also performed research on SARS-CoV-2. Of special interest is our interest in the antiviral cellular immune response against HIV-1. The experimental research of the present position is focused on in vitro and ex vivo evaluation of immune cells and modulation of their antiviral capacity against HIV-1.

Your mission

The successful applicant will perform his/her tasks in the experimental research group of Prof. Anders Sönnerborg. The main working tasks will be on evaluation of the antiviral effects of natural killer cells on HIV latency/replication and modulation of these effects by drug compounds. This includes analysis of cellular and molecular mechanisms within both NK cells and HIV-1-infected cells in in vitro and ex vivo experiments. The applicant will perform their research within the framework of Prof. Anders Sönnerborg’s and Dr. Robert van Domselaar’s HIV projects and give intellectual and administrative support to other members of the research group.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

It is particularly meritorious that the applicant has shown:

Knowledge in virology and/or viral immunity, especially in relation to HIV and the pathogenesis of viral diseases.
Knowledge in cell culture techniques and analysis tools relevant to viral pathogenesis and/or cellular immunity.
Experience of research in BSL-2 and/or BSL-3 laboratory facilities.
Experience in primary cell cultures, in particular primary NK cells and/or primary T cells.
Excellent knowledge in English, written and spoken, is a requirement.

It is meritorious that the applicant has shown:

Skills in the following techniques:
i) cell (co-)culture systems, immune cell isolation from peripheral blood, cellular functionality assays, genetic modifications of cells.
ii) antiviral assays, multi-colour flow cytometry analysis.
iii) other techniques; DNA/RNA isolation from tissues or cells, ELISA, immunofluorescence, immunoprecipitation, luciferase reporter assays, PCR, quantitative PCR, SDS PAGE, western blotting, proteomics.
The person should be well organized, service-oriented, and flexible.
A positive and collaborative attitude to work in a dynamic environment which includes strong social skills.
A publication list with first author publications in international peer-reviewed journals.
Own grants received in competition after peer-review.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

The Department of Medicine, Huddinge (MedH)

Infectious Diseases and Dermatology Unit

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 2023-05-31.

The application is to be submitted through the Varbi recruitment system.

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