Research specialist in anti-retroviral compounds - Hiring in process/Finished, not possible to apply

Do you want to contribute to better health for all?

Within our research group you will find a unique opportunity to work closely together with cutting edge researchers in the intersection between infectious diseases, antiviral treatment, prophylaxis and viral pathogenesis. We offer an engaging and international research environment where you may contribute to high quality research on an internationally competitive level.

Description of the subject area

Our research group has a strong focus on pathogenesis, treatment, prophylaxis and cure of HIV infection. More recently research is also performed on SARS-CoV-2. Of special interest is our interest in the evaluation of novel anti-viral compounds. The experimental research of the present position is focused on in vitro and ex vivo evaluation of compounds which exhibit anti-retroviral properties.

Your mission

The successful applicant will perform his/her tasks in the experimental research group of Professor Anders Sönnerborg. The main working tasks will be on evaluation in vitro and ex vivo of the properties of compounds both for regulation of HIV latency/replication and for prophylaxis against viral infections. This includes mechanisms, pathways, efficacy, and resistance development. The applicant will perform own research within the framework of Professor Sönnerborgs HIV projects and give intellectual and administrative support to other members of the research group.

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

Assessment criteria

It is particularly meritorious that the applicant has shown

• Profound knowledge in biology with a focus on virology, especially HIV, and the pathogenesis of viral diseases.
• Advanced knowledge of evaluation of anti-viral efficacy in vitro with special focus on HIV
• Advanced knowledge in evaluation of antiviral prophylaxis with special focus on sexually transmitted infections.
• Advanced knowledge in antimicrobial resistance with special focus on anti-retroviral resistance.
• Knowledge in modern biotechnological techniques to be used for the description of viral pathogenesis.
• Experience of research in BSL-3 laboratory facilities
• Experience in setting up virological assays to evaluate antiviral efficacy, and host responses.
• Experience in setting up assays for evaluation of efficacy of microbiocides.
• Skills in the following techniques: i) cell culture systems; both cell lines, primary cells and co- cultures, immune cell isolation from peripheral blood, cellular functionality assays, transfections; ii) antiviral assays; iii) other techniques; DNA/RNA isolation from tissues or cells, ELISA, immunofluorescence, immunoprecipitation, luciferase reporter assays, PCR, quantitative PCR, SDS PAGE, western blotting, proteomics.
• Excellent knowledge in English, written and spoken, is a requirement.
• The person should be well organized, service-oriented, and flexible.
• A positive and collaborative attitude is a pre-requisite for working in the Sönnerborg group and a great emphasize is put on the collaborative attitude of the applicant. Thus, of importance is that the candidate is well acquainted with collaborative work in a dynamic environment which includes strong social skills.
• A strong publication list as first or last author in international peer-reviewed articles published in journals with IF over 10.
• Recent or ongoing approved grants obtained in competition.

It is meritorious that the applicant has shown

• Knowledge of the impact of microbiota on effects of antiviral drugs and microbiocides
• Knowledge in various cellular and molecular techniques that allow genetic modification of cells ranging from cloning to transduction experiments.
• Experience of teaching students
• Experience of collaboration with clinical researchers
  
  

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

The Department of Medicine, Huddinge (MedH)
Infectious Diseases and Dermatology Unit
Choose to work at KI - Ten reasons why

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 2023-05-11.

The application must be submitted through the Varbi recruitment system.

We apply a 6-month trial period for all permanent employments.

Want to make a difference? Join us and contribute to better health for all