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Ana Mendanha Falcão has recently established her research group, which is focusing on the role of the choroid plexus in diseases such as multiple sclerosis. Her team aims to investigate the choroid plexus as a source of biologically active molecules to the central nervous system, in order to influence disease dynamics. The choroid plexus will be studied as an alternative target for disease therapies since it can be modulated by peripheral blood and it can substantially alter the brain composition both in terms of biologically active molecules and immune cell content.
The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. Our research group has performed single nuclei/cell RNA-Seq and identified several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019). Our findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought.
Read more:
http://www.icvs.uminho.pt/about-icvs/people/analuisafalcao
https://ki.se/en/mbb/goncalo-castelo-branco-group
The position is based at unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden, at the Ana Mendanha Falcão research group (also at University of Minho, Portugal) and joint with Castelo-Branco research group.
Falcao’s and Castelo-Branco's research groups have ongoing projects with single-cell and bulk transcriptomics, and the successful candidate will be actively working in specific projects under Falcao’s group together with Castelo-Branco’s group. The successful candidates will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists.
We are looking for a highly motivated, driven, inquisitive and enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidates should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory. The applicants must have either a Master in bioinformatics and computational biology or PhD degree, and strong programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science a big data. The successful candidate will be working in specific projects involving single-cell omics on the areas of interest Falcao’s group. Research experience and expertise in analysis of sequencing data is highly desirable. Wet lab experience is not required but it is an advantage.
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.
Location: Solna (Stockholm, Sweden)
An employment application must contain the following documents in English:
Welcome to apply at the latest 2020-07-03
The application is to be submitted through the Varbi recruitment system.
All applicants will be informed when the recruitment is completed.
Type of employment | Temporary position |
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Contract type | Full time |
First day of employment | October 2020 |
Salary | Monthly salary |
Number of positions | 1 |
Full-time equivalent | 100 % |
City | Stockholm |
County | Stockholms län |
Country | Sweden |
Reference number | STÖD 2-2504/2020 |
Contact |
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Union representative |
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Published | 02.Jun.2020 |
Last application date | 03.Jul.2020 11:59 PM CEST |