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The laboratory of Björn Reinius, Karolinska Institutet, Stockholm, Sweden is seeking a bioinformatician / data analyst as well as a wet-lab-oriented molecular biologist or biochemist. – Come and join our team!
Lab webpage: www.reiniuslab.com
Karolinska Institutet profile: https://ki.se/en/people/bjrein
Our research
The Reinius lab investigates fundamental aspects of gene regulation, and have a particular edge in X-chromosome inactivation and dosage compensation. Female cells contain two X chromosomes while male cells contain only one, and to balance the X-gene dose in female cells one X-chromosome copy is kept transcriptionally silenced by the process of X-inactivation. At the same time, the remaining active X chromosome is hyper activated to balance the gene dose with the diploid autosomal part of the genome. Because of these chromosome-wide features, the X-chromosome is a remarkable system for dissecting major mechanisms of transcriptional regulation. By characterizing the states and epigenetic framework of X-chromosome inactivation, we reveal key features of transcriptional regulation and systems biology.
Reinius and colleagues recently pioneered the use of single-cell RNA-seq in the study of X-inactivation (Science 2014, Nature Reviews Genetics 2015, Cell 2016, Nature Genetics 2016, bioRxiv 2019 etc., see Publications on our Lab webpage). To expose mechanisms of dosage compensation, we employ newly developed concepts and molecular techniques, including single-cell RNA-sequencing, chromatin accessibility and modification assays, mouse transgenics, and advanced computational methods for the analysis of allele-specific gene expression. The expected outcome of the research is of broad biological significance, and has the potential to reveal molecular mechanisms underlying variable expressivity and incomplete penetrance of X-linked genetic disorders.
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Entry requirements
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.
Application process
An employment application must contain the following documents in English or Swedish:
The application is to be submitted through the Varbi recruitment system.
Type of employment | Temporary position |
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Contract type | Full time |
First day of employment | Upon agreement, at latest Sept. 2019 |
Salary | monthly |
Number of positions | 2 |
Full-time equivalent | 100% |
City | Solna |
County | Stockholms län |
Country | Sweden |
Reference number | 2-2172/2019 |
Contact |
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Union representative |
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Published | 05.Apr.2019 |
Last application date | 15.May.2019 11:59 PM CEST |