Research Specialist in Signal Transduction in Pancreatic Islet Cells - Hiring in process/Finished, not possible to apply

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Divison

Signal Transduction Laboratory, Rolf Luft Center for Diabetes and Endocrinology, Department ofMolecular Medicine and Surgery, Karolinska Institutet. 

Description of the subject area

We are focused on studying the signalling crosstalk within the pancreatic islet and then more specifically at the beta-endothelial cell interface in vivo, and its impact on insulin secretion from beta cells as well as overall glucose metabolism. Our aim is to gain in depth understanding of the plasticity in beta-endothelial cell paracrine signalling under physiological and diabetic conditions, mainly by in vivo imaging of transplanted islets in the anterior chamber of mouse eye, in combination with further mechanistic studies.

Your mission

The Rolf Luft Center for Diabetes and Endocrinology is now recruiting a Research Specialist who will work in close collaboration with the rest of the team mainly on obtaining mechanistic knowledge on the regulation of islet function in vivo. The successful applicant will join and enhance ongoing efforts in investigating the physiological activities of intra-islet VEGF-A/VEGFR2 pathway in vivo, and further examining its modifications under diabetic conditions as well as the metabolic implications in an obese animal model.

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a PhD in biology/cell biology, the applicant must have documented research expertise in both islet biology and vascular biology after defending the doctoral dissertation. The applicant should have deep knowledge in islet and vascular endothelial cell physiology as well as pathology. He/she must be familiar with in vitro and in vivo techniques for investigating signal-transduction and functionality of islet and vascular cells.

Additional requirements:

• Demonstrated research experience in endothelial cell derived angiocrine factors
• A good understanding of in vivo imaging techniques and data analysis is desirable
• Self-initiative and ability to work independently as well as being part of a team
• Excellent English proficiency (written and verbal) and project coordination skills

Assessment criteria

It is particularly meritorious that the applicant has shown

• Competence in in vitro and in vivo microscopy, islet transplantation, in vivo investigation of vessel morphology as well as physiology

It is meritorious that the applicant has shown

• Competence in animal research

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Read more: Signal Transduction

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest November 23, 2022

The application must be submitted through the Varbi recruitment system.

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