Research specialist in single-cell genomics and malaria

Do you want to contribute to improving human health?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. Our key words are multidisciplinary, bridging, national and international collaborations.

As a research specialist with us you will have an opportunity to develop and apply single cell -omics to define host immune response during malaria infection in longitudinal cohort samples.

Description of the subject area

Developing and application of single cell transcriptomics (-omics) to understand host immune response during malaria infection.

Your mission

You will become a part of a highly dedicated and international team, focused on innovative research in single-cell (-omics) technologies in malaria with a broader objective of using an integrated approach towards the elimination of the disease in endemic countries.

The main work duties are:

• Performing state-of-the-art single-cell sequencing experiments on different platforms (e.g. 10X Chromium, Parse Biosciences, Smart-seq, etc).
• Analyzing next-generation sequencing data, preferably WGS/WES data from field samples.
• Processing raw sequencing data to generate gene expression profiles, perform clustering of cell populations, and analyze trajectory/lineage, often using R, Python, or specialized bioinformatics tools
• Handling, managing and processing field samples.
• Providing expertise and advice to researchers and students on single cell technologies and analysis.
• Writing manuscripts and applying for grants.

Development and implementation of new methods for NGS-based single-cell and spatial tissue analyses

Eligibility requirements

For employment as Research Specialist at Karolinska Institutet, the eligibility requirements stated in the Guidelines for non-teaching positions at Karolinska Institutet are applied in relation to the established profile of employment.

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having a foreign degree deemed equivalent to a Swedish doctoral degree, the applicant must have demonstrated research expertise as well as have documented postdoctoral research experience.

Other requirements for the position:

• A PhD in Computational biology/Genomics/Bioinformatics or equivalent.
• A proven experience in analyzing next-generation sequencing data, preferably WGS/WES data from field samples. Processing raw sequencing data to generate gene expression profiles, perform clustering of cell populations, and analyze trajectory/lineage, often using R, Python, or specialized bioinformatics tools.
• In-depth understanding and working with single-cell sequencing data from different molecular modalities.
• In-depth understanding and interest in malaria research.
• At least three publications in which you played a leading or major role in the analysis of sequencing data.
• Previous experience working in communities living in malaria-endemic regions and setting up longitudinal cohorts, sample collection and processing.
• A strong collaborative attitude with the ability to thrive in multicultural settings and possibility of traveling abroad for field-based research.
• Ability to independently organize your own work routine and flexibly adapt your weekly schedule to emerging requests.
• Fluency in oral and written English.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Choose to work at KI - Ten reasons why

https://ki.se/en/people/akira-kaneko#about-me

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: PhD certificate, resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The application must be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all!