Postdoctoral Computational Scientist

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC has about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

MTC is looking for a post-doctoral computational scientist to join Professor Gunilla Karlsson Hedestam's group to contribute to the group's project concerning the analysis of immune repertoires and variation in adaptive immune receptor genes from Next Generation Sequencing (NGS) data. The group's goal is to increase our understanding of how inherited variations in T and B cell receptor genes influence the diversity and function of adaptive immune responses. 

Your mission

Modern immunology research generates large datasets from high-throughput sequencing techniques. The Karlsson Hedestam group analyzes highly diverse adaptive immune receptor repertoires and studies the role of germline-encoded polymorphism for antigen-specific responses. The group is now seeking a post-doctoral scientist who is interested in using these large datasets for in-depth investigations about how the adaptive immune response differs between persons. Specifically, the group is looking for a computational scientist with experience in data analysis, statistics, and visualization. The appointment is for a purely computational scientist. It will not involve any wet lab work.

Your profile

To be eligible for employment as a postdoctor, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

A selection will be made among qualified applicants using the following bases of assessment:

• A Ph.D. in Bioinformatics, Computational Biology, or a closely related field
• At least 5 years’ experience working with data analysis and bioinformatic analysis
• Strong interdisciplinary foundation bridging immunology and computer science, with a deep understanding of probability theory, advanced statistics, and statistical modeling
• Proven expertise in adaptive immune receptor and repertoire analysis using machine learning and statistical methods
• In-depth knowledge of T-cell and B-cell receptor biology, along with adaptive immune repertoire sequencing data preprocessing
• Experience in developing computational methods for analyzing high-dimensional biological data
• Experienced in relevant programming languages and skills in data science (data cleaning, scripting, visualization, etc)
• Advanced proficiency in Python, R, and Bash, with experience using GitHub or related version control systems
• Experience working in Linux environments and high-performance computing systems
• Demonstrated success in interdisciplinary collaborations with both experimental and computational teams
• Motivated, independent, and well-organized with excellent communication skills in spoken and written English
• Ability to work in a multidisciplinary research environment
• Highly driven and motivated to solve problems, and able to work independently while also being able to communicate effectively with other members of the team

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

http://www.ki.se/en

https://ki.se/en/mtc/gunilla-karlsson-hedestam-group

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 11 February 2025.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!