Postdoctoral position in CNS regeneration

Do you want to contribute to top quality medical research?

The Llorens laboratory offers a vibrant, stimulating and international environment. We are part of the Department of Cell and Molecular Biology (CMB). CMB is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum houses approximately 1,200 researchers and other personnel and allows expensive equipment to be shared and utilized more effectively.

Division

Our lab is interested in stimulating regeneration in the mammalian central nervous system (CNS). We aim to uncover the principles of cell fate regulation during development and repurpose them for regeneration. We use a multidisciplinary approach that involves stem cell biology, systems biology, computational biology, molecular engineering, and mouse models of disease.

Using single cell multiomics, we recently discovered a latent regenerative potential in adult spinal cord stem cells and designed a targeted intervention to elicit such potential. This intervention stimulated endogenous remyelination and improved axon conduction after injury (Llorens-Bobadilla et al. Science 2020). These studies suggest that activating the right endogenous genes after injury could unlock the dormant regenerative potential of resident stem cells.

The current projects aims at using novel single cell and spatial genomics technologies, in combination with CRISPR-based tools that we have developed to systematically screen and identify pro-regenerative genes in vivo.

Link to the lab website: https://ki.se/en/cmb/enric-llorens-group

Duties

We are seeking a highly motivated and enthusiastic postdoctoral fellow to apply novel spatial genomics technologies and in vivo CRISPR screening to identify pro-regenerative strategies in the injured CNS.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for highly motivated, independent, and self-driven candidates, with a strong track record and relevant experience during the PhD. The successful applicant is expected to have a background and a strong interest in one or several of the following areas: single cell and spatial genomics, gene delivery, CRISPR, neuroscience, stem cell biology and mouse models of CNS injury or disease. A documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English. Experience with molecular engineering, CNS injury models, viral gene delivery and/or bioinformatics will be considered an advantage.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Stockholm

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)
A motivation letter
Names of three referées

The application is to be submitted through the Varbi recruitment system.

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