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The Department of Neuroscience consist of 30 research groups studying the function of the nervous system in health and disease. The laboratory of Dr. Gilberto Fisone is interested in the characterization of mouse models of neurodegenerative and psychiatric diseases. One line of research is devoted to the study of neuropsychiatric complications linked to administration of dopamine replacement therapies. The lab needs to strengthen its research on these conditions, which include impulse control and addicitive-like disorders. This will provide an ideal complement to clinical research on neurodegenerative disorders currently carried out at Karolinska Institutet. Dr. Fisone’s lab is located in the Biomedicum building, which hosts a multidisciplinary environment and top-level core facilities.
Your mission
The successful candidate is expected to participate in the analysis of molecular and circuit abnormalities involved in dopamine dysregulation syndrome and similar compulsive disorders associated to Parkinson’s disease therapy. Work will be based on the use of a rodent model of PD. The final goal will be to provide information for the development of therapeutic approaches to combine with those currently used to treat Parkinsons’ disease.
Your profile
The candidate should be familiar with basic in vitro techniques, such as western blotting and immunofluorescence, and stereotaxic manipulations of mice, particularly microinjections of catecholamine toxins, such as 6-hydroxydopamine. The candidate should also be acquainted with behavioral analysis of rewarding and addictive mechanisms in mice. Knowledge on handling of transgenic mouse lines will also be considered.
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.
Location: Solna
Choose to work at KI – Ten reasons why
Welcome to apply at the latest October 25.
The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.
Type of employment | Permanent position |
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Contract type | Full time |
First day of employment | November |
Salary | Monthly salary |
Number of positions | 1 |
Full-time equivalent | 100% |
City | Solna |
County | Stockholms län |
Country | Sweden |
Reference number | STÖD 2-3878/2023 |
Contact |
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Union representative |
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Published | 11.Oct.2023 |
Last application date | 25.Oct.2023 11:59 PM CEST |