Postdoctoral Researcher in immunotherapy

Do you want to contribute to top quality medical research?

We are seeking a talented and motivated individual to join the team of Associate Professor Isabelle Magalhaes as a Postdoctoral fellow to contribute to an exciting project on CAR T cell therapy. The work will be carried out at the Division of Therapeutic Immunology and Transfusion Medicine at the Department of Clinical Science, Intervention and Technology, and done in close collaboration with the group of Professor Michael Uhlin.

Your mission

Our project’s primary objective is to further improve CAR T cell therapy, particularly in the context of solid tumors, by optimizing CAR T cell production (e.g. culture conditions), choice of T cell source/subset for CAR production and CAR design improvements. Our group has established CAR T cell preclinical models of solid tumors (i.e. ovarian cancer, Schoutrop et al., Cancer Res 2021; Schoutrop et al., JITC 2023) and evaluated the efficacy of mesothelin-targeting CAR T cells in vitro and in vivo.

You will be involved in producing CAR T cells and evaluating their effector functions in vitro and in vivo and developing orthotopic animal models of cancer. We aim to recruit an independent and forward-thinking person also willing to generate and test experimentally improved CAR designs. The methods used will include cell culture, genetic modification, flow cytometry, functional analysis and animal experiments. In addition, you will be encouraged to mentor students and participate in grant-writing.

Your profile

You have a PhD in the field of immunology or immunotherapy of cancer and a great interest in immunotherapy.

Required skills:

At least one first author publication in a recognized peer-reviewed journal
Experimental knowledge of immunological methods
Hands on experience with animal models of cancer
Effective communication in English, both spoken and written
Excellent communication skills and capacity to work collaboratively
Ability to work independently and manage multiple projects in parallel

Desirable skills:

Hands-on experience with cell culture, cell sorting, and advanced flow cytometry
Experience with viral vector for cell transduction

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 17th October 2023.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all