Postdoctoral Researcher in Protein-RNA Biochemistry

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

Our laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equipped with state-of-the-art instrumentation and core facilities.

A post-doctoral position is available under the supervision of Dr. Ilaria Piazza to work in close collaboration with the laboratory of Dr. Vicent Pelechano. The Piazza laboratory (http://thewittysquare.eu) uses mass spectrometry-based approaches to study protein interactions in cell and tissues with proteomics. The Piazza laboratory is based both at the Karolinska Institute in Stockholm (SciLifeLab) and at the Max Delbrück Center for Molecular Medicine in Berlin. The successful candidate will work on a collaborative project with the laboratory of Dr. Vicent Pelechano (http://pelechanolab.com/). The Pelechano laboratory integrates experimental and computational approaches to tackle fundamental biological questions with medical relevance using innovative genome-wide techniques. You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genomic and proteomic approaches with the molecular dissection of fundamental biological problems.

Are you interested in Protein-RNA interactions and their role in disease? Would you like to contribute to the development of cutting-edge proteomic and genomic technologies? Come and join us at SciLifeLab!

Your mission

We are seeking a highly motivated postdoctoral fellow with a passion for developing experimental methods to join our team. In this role, you will be involved in a groundbreaking project aimed at advancing the study of protein-RNA interactions through the integration of proteomics and genomics, making use of the expertise of the Piazza and Pelechano laboratories. With proof-of-concept already established, you will work to refine and optimize the method to achieve broad applicability and high reproducibility. You will have the opportunity to apply this novel approach to explore pressing biomedical questions, such as elucidating the key features of proteins that govern RNA binding specificity and leveraging this knowledge to advance treatments for human tumors and immunotherapies.

You will work on an exciting multidisciplinary project integrating multiomics approaches that aims to understand the crosstalk between RNA and in bulk and at single cell level. You will have access to state-of-the-art instrumentation including mass spectrometers for single cell proteomics analysis and be involved in international cross-disciplinary collaborations.

The candidate is expected to contribute his/her own ideas and take a strong lead in the experimental design and data interpretation. The candidate will perform original research in genomics and/or proteomics, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate will be responsible for the experimental design, implementing analytical pipelines and integrate different kinds of genomic data to answer biologically relevant questions.

The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment.

This position is based in Stockholm (Sweden), but you will have the opportunity to work in close collaboration with the Piazza laboratory located at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) in Berlin (Germany). Working language is English.

If you are a dedicated researcher with a desire to drive innovation in the field, we encourage you to apply for this exciting position.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Requirements for the position:

A PhD in RNA/protein biochemistry, systems biology, molecular biology or equivalent
A strong interest in proteomics and/or genomics and quantitative biology
At least one of the following backgrounds:
- o For proteomics: general knowledge of quantitative proteomics data acquisition and data analysis
- o For genomics: knowledge of NGS library generation, single-cell approaches (e.g., RNA-Seq, ATAC…) and NGS data analysis
Curiosity and motivation in learning the complementary -omics approach (e.g: a candidate with a PhD in genomics should be eager to use proteomics strategies or viceversa).
Ability to work independently and in teams
Excellent communication skills
A solid experimental or computational background
A strong publication record as primary author
Excellent communication skills in English

Meritorius for the position:

Previous experience with work with human cancer cell lines and stem cells is a plus
Programming skills with Python or R is a plus

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

https://thewittysquare.eu

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 20th August 2023.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all