Postdoctoral Researcher in Computational RNA biology and Metagenomics - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations. Vicente Pelechanos laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to one of the largest sequencing cluster in Europe.

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes and are passionate about RNA biology (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

Are you interested in the crosstalk between ribosome dynamics and mRNA decay? Would you like to develop cutting-edge genome-wide technologies to study drug-microbiome interactions and improve our understanding of antimicrobial resistance? Come and join us at SciLifeLab!

Your mission

The available postdoctoral position concerns developing and applying novel computational approaches to study gene expression and RNA metabolism in complex bacterial samples. The candidate will focus on the computational analysis and multiomic integration of a wide variety of genomic data (metagenomics, metatranscriptomics, metadegradomics and phenotypic data). This will include the study of the crosstalk between translation regulation and mRNA decay in response to environmental and drug perturbations using novel tools that our laboratory has recently developed (Huch, Nersisyan et al. Nat microbiology 2023).

The candidate will perform original research in genomics and computational biology, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate will use multiple model organism, from isolated bacteria and fungi to complex mixtures. The selected applicant will be responsible for developing and implementing analytical pipelines and integrate different kinds of data to answer biologically relevant questions. The successful candidate will take a strong lead in the experimental design and collaborate with other team members. The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants to this position should have a PhD in Bioinformatics, Microbiology, Genetics, Molecular Biology, or related fields.

The successful applicant should have experience interpreting biological data and experimentally testing their hypothesis. Previous experience on the computational analysis of metagenomics or metatranscriptomics are essential. Experience in Ribosome dynamics, RNA biology and gene expression will be highly considered. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential. Preferred experience also includes familiarity with bioinformatics, NGS data analysis, bioinformatic package development, Python and R scripting languages. Good interpersonal skills and ability to work in teams is essential. Previous experience in bacteria-drug interaction, antimicrobial resistance or microbial will be meriting.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-06-08

The application is to be submitted through the Varbi recruitment system.

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