Postdoctoral Researcher in studies of stem cell models for Parkinson’s disease - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

A postdoctoral position is available in Thomas Perlmann’s lab at the Department of Cell and Molecular Biology at Karolinska Institutet. The lab is located at Biomedicum, a research building with excellent infrastructure and world-leading research in many areas of biomedical science.

The lab’s focus is on the development and maintenance of dopamine neurons within the ventral midbrain. We are unraveling the signaling and transcriptional regulation that govern these cells' specification, differentiation, and maintenance. The studies have relevance for regenerative medicine and neurodegeneration concerning Parkinson’s disease and other brain disorders. We are using mouse genetics and other methods, including single-cell RNA sequencing, in our studies. In collaborative projects, we also focus on regenerative strategies such as stem cell therapy and the maintenance of dopamine neurons in the human brain.

Your mission

Your responsibility will be to lead a project aiming at the development of stem cell-based Parkinson’s disease models. The project uses human embryonic stem cell lines that are differentiated into neurons and analyzed both in vitro and in vivo after transplantation to rodent brains.

Your duties will be to conduct experiments in cell culture and rodent models of Parkinson’s disease. This will involve demanding animal work and analysis of the behavior and tissue histology of different mouse models.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The applicant is highly motivated and can collaborate and function well in a team. Skills in the following areas are a requirement: animal surgery, basic locomotor testing of mice, tissue culture, differentiation of human embryonic pluripotent cells, and histological methods. An appropriate certificate for mouse animal work (FELASA C or equivalent) is a requirement for the position. Excellent English oral and writing skills are a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Stockholm

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Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

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