Postdoctoral researchers (2 positions) in neurodegenerative disease mechanisms with focus on Alzheimer disease therapy - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

We are looking for two postdocs full-time for 1-2 two years the positions will be located at Campus Solna in BioClinicum and you will both work on the same project. The project aims to explore novel therapeutic concepts for Alzheimer disease (AD) based on regulation of function of molecular chaperones or other systems responsible for intracellular protein folding and degradation. The project involves studies of biological effects using human cells and AD-related animal mouse models.

Your mission

 The position involves analysis of potential drugs that target processes relevant for neurodegenerative diseases, mainly AD. Specifically, the function of regulatory components and potential drugs will be assessed in cell lines and mouse models, which are related to AD. Alzheimer disease and other neurodegenerative diseases are associated with aggregation of certain proteins such as beta-amyloid and tau.

This project focuses on tau aggregation by development of small molecule ligands, targeting protein-protein interaction. We are also interested in the connection between tau aggregation and insulin resistance. We combine structural biology techniques such as computer aided drug design, biochemical and biophysical methods to develop novel ligands as potential drug candidates for AD. We investigate biological effects of these molecules and validate them in proof-of-concept experiments. The duties include in silico drug design using virtual screening, hit-to-lead compound development, lead optimization, implementation of biochemical assays for compound screening, target characterization in vitro in cell models and in vivo in various AD-related mice models

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

You should preferably have a PhD in biomedicine, cell biology, biochemistry or similar topic. Documented experience with cell and animal models in neurodegenerative diseases is qualifying, including scientific publications in this research area. You are expected to have a strong drive to pursue experimental research and an ambitious, innovative attitude. The project is pursued in collaboration with other researchers why good collaborative skills are necessary. Good ability to speak and write in English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 8th of september 

The application is to be submitted through the Varbi recruitment system.

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