Postdoctoral Researcher in the role of the intestine in cardiometabolic disease

Do you want to contribute to top quality medical research?

Your mission

Cardiometabolic disease is to a large part underlying the vast increase in non-communicable diseases observed in recent years; particularly relevant for the current project are the components obesity, insulin resistance, non-alcoholic fatty liver disease(NAFLD)/steatohepatitis (NASH) and atherosclerotic cardiovascular disease. The intestinal compartment is the first line of contact with food and serves as integrator and relay for signals derived from the interplay of microbiota, food, different epithelial cell types and immune cells. The current project aims to mechanistically explore how these interactions impact cardiometabolic disease and to delineate the signalling pathways involved. The intended experiments span from cell culture to in vivo models of disease (including work with germ-free models). Results from multiple layers of information derived from bulk RNA and single cell sequencing together with proteomics and metabolomics will be integrated to discover and map novel signaling pathways. These approaches are complemented with lipid biochemistry and in vivo characterization of metabolism using dynamic tests.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

To qualify, you should have a background in biomedical sciences with interest and experience regarding the work with cell culture as well as with preclinical animal models. In addition, ample knowledge with respect to general laboratory techniques such as cloning and qPCR is a requirement. Good proficiency in English, both oral and written is required.

Experience with in vivo studies in disease models is particularly of advantage. Prior knowledge in bioinformatics (working with large data sets as e.g. generated by RNA sequencing), metabolism, intestinal (patho)physiology, microbiota, (primary) cell culture and molecular biology is also an advantage.

We are looking for a highly motivated, structured, enthusiastic and scientifically driven candidate interested in exploring how organs mechanistically communicate to regulate metabolism. The person should exhibit a high degree of independence but on the other hand also value a collaborative approach to science and enjoy working in a team.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 14 June 2022.

The application is to be submitted through the Varbi recruitment system.

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