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The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 540 employees and a revenue 2023 of 530 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.
The Division of Neurogeriatrics and the research focus
The research at the division of Neurogeriatrics is focused on neurodegenerative diseases, in particular Alzheimer’s disease and aims to translate findings from basic research into clinical practice. The position is affiliated to Bengt Winblad’s group that works with early phase drug discovery for AD and other related diseases. We have access to world class infrastructure in the form of several high-end core facilities situated at Karolinska Institutet.
Duties
We are looking for an enthusiastic and highly motivated scientist who is interested in working in a multi-disciplinary team at the forefront of translational Alzheimer's disease research. The position is mainly focused on research work related to development of small molecule ligands targeting protein-protein interaction drug targets in AD and related neurodegenerative disorders. In particular, we combine structural biology techniques such as macromolecular crystallography, biophysical and biochemical methods, and computer aided drug design to develop novel ligands as potential drug candidates for AD and related diseases.
The successful candidate will work independently, be part of a team to design drugs for important targets for treating AD and other dementias. The duties include in silico drug design using virtual screening, hit-to-lead development, lead optimization, biochemical assay development and compound screening. Prior experience with protein expression and purification in bacterial and human cell culture systems, protein-protein interaction analysis, and structure based drug design using x-ray crystallography is highly desirable.
The applicant is expected to develop an independent research line with a strong profile, writing scientific articles in leading journals, and present research results at scientific conferences and for the public. Furthermore, the person must apply for his / her own research grants and ensure financing for future research, as well as supervising graduate students in the research group. Also teaching at different levels and courses are included in the service. This employment as Assistant Professor is time limited for 4 years with the right to apply for promotion to Senior Lecturer.
The successful candidate should be ambitious, focused, hard-working, and possess good written and communication skills in English. Good interpersonal and social skills are also appreciated.
Eligibility requirements
Those eligible for employment as an Assistant Professor are individuals who have been awarded a PhD or attained equivalent research competence. Preference should be given to those who were awarded a PhD or attained equivalent research competence no more than five years prior to the expiry of the application period for the position of assistant professor.
Those who have been awarded a PhD or attained equivalent research competence earlier may however be considered if special grounds exist. Special grounds refer to illness or parental leave.
To qualify, the applicant must hold a PhD degree and post-doctoral experience in the field of medicinal chemistry, computational chemistry, structural biology, or biochemistry and a demonstrated ability to conduct original and innovative research. The ideal candidate will have the broad knowledge and research experience in structure based drug design and computer aided pre-clinical drug discovery field. Established record of high-quality scientific research and publications. Ability to work both independently and as a member of a collaborative, scientific team. The successful candidate will also be expected to have excellent verbal and written English skills and to write and apply for grants. We are interested in an individual that is creative, highly motivated and aim to establish world leading research with a clear technological focus incorporating potential translational value.
Bases of assessment
Scientific expertise will be most important when assessing applicants.
Application process
An application must contain the following documents in Swedish/ English: curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio).
The application is to be submitted through the Varbi recruitment system
Promotion of Assistant Professor to Senior Lecturer
See the instructions regarding the Appointment Procedure for Teachers at Karolinska Institutet chapter 3.3
An Assistant Professor can apply for promotion to Senior Lecturer. An application is submitted to the Recruitment Committee. In order to be promoted to Senior Lecturer after an assessment by the Recruitment Committee, the applicant must meet the criteria below. The Assistant Professor can choose between two different promotion tracks; promotion to Senior Lecturer with focus on Research or promotion to Senior Lecturer with focus on Education and research.
Promotion of Assistant Professor to Senior Lecturer with focus on Research Assessment criteria
Promotion of Assistant Professor to Senior Lecturer with focus on Education and research
Assessment criteria
If the applicant is deemed to fulfil all of the above criteria, they will be assessed by two experts in their field and must meet the eligibility requirements that apply to appointments as a Senior Lecturer at Karolinska Institutet.
Type of employment | Temporary position |
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Contract type | Full time |
Number of positions | 1 |
Full-time equivalent | 100% |
City | Solna |
County | Stockholms län |
Country | Sweden |
Reference number | 2-1899/2019 |
Contact |
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Union representative |
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Published | 22.Mar.2019 |
Last application date | 12.Apr.2019 11:59 PM CEST |