Postdoctoral Researcher in circular RNA expression in medulloblastoma - Hiring in process/Finished, not possible to apply

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

This is an opportunity to work within a research environment that promotes novelty and innovation, highlighted by an early focus on circular RNAs years before they reached their current status of biological significance.

Your mission

The successful candidate will work within an international group that has active collaboration with researchers in different parts of the world. The main tasks will be to isolate intact RNA from a large collection of medulloblastoma samples provided via national and international biobanks. Subsequently, the circular RNA fraction will be enriched and subjected to RNA sequencing. Using bioinformatic tools, sequence reads that correspond to circular RNA molecules will be selected. Once a robust list of circular RNAs deregulated in medulloblastoma versus normal cerebellum is identified, a functional analysis for their role in tumor growth through in vitro and in vivo approaches will be implemented.    

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Experience in bioinformatic detection of circular RNA expression is required as well as knowledge of the role of Hedgehog signaling for medulloblastoma development.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

https://ki.se/en/bionut/circular-rnas-in-cancer-development-peter-zaphiropoulos

Application

An employment application must contain the following documents in English:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)