Researcher in Translational Disease Models - Hiring in process/Finished, not possible to apply

Do you want to contribute to improving human health?

The laboratory of Professor Thomas Helleday and Deputy group leader Ulrika Warpman Berglund provides an excellent translational and scientific environment. The multidisciplinary research group is located at Science for Life Laboratory and consists of PhD students, postdocs and senior scientists within biology, biochemistry, medicinal chemistry, and pharmacology, many with experience from the pharmaceutical industry.

Your mission

We are looking for a highly motivated and lab experienced Research Scientist to the Helleday group. Your main task will be to plan and lead the work of the Disease Models team, part of the Helleday laboratory. Your work will be very varied, and in addition to lead the team you will also work with uncovering molecular mechanisms using in vivo models, immunohistology staining techniques and several molecular biology techniques.

In more detail, you will contribute to a further understanding of the role of DNA repair and metabolisms proteins in cancer and characterise small molecules inhibiting these pathways. For instance, we have identified and developed a MTH1 inhibitor, Karonudib, that is presently under clinical development. To support the clinical findings and development we still need to further investigate biomarkers, combination treatments, potential resistance mechanisms and obtain a deeper understanding of the mechanism of action of the compound.

The Disease Models team’s role is to validate the basic science findings in relevant disease models, investigate pharmacokinetic properties of the novel compounds, PK/PD relationships, biomarkers and perform translational research.

The team, today consists of two in vivo pharmacologists, but may also be extended with master students as well as PhD students for which you will be responsible for. That is, you will plan, lead and execute the work of the team and be responsible for the delivery of high-quality data in a timely manner from your team and work closely with the other multidisciplinary teams to enable further understanding of the mechanisms and the target of interest, PK/PD understanding and identification of biomarkers.

Your profile

A person is eligible to be appointed Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after the defense of his or her doctoral thesis.

The following qualifications are required:

• A degree in Veterinary Medicine.
• A PhD in Molecular Medicine/Molecular Biology or Biotechnology.
• Previous documented experience establishing disease models within oncology and inflammatory disease.
• Previous documented experience of design, execution and analysis of different anti-cancer and anti-inflammatory drugs in disease model and should have experience in lab animal gross pathology as well as in histopathological analysis.
• FELASA certificate
• Cell lab experience such as handling and culturing of various cells both blood and solid cancer cells
• Previous documented experience with standard cellular techniques, FACS, cellular viability/survival assays and molecular biology techniques, eg qPCR, Western blot, are a requirement.
• Previous documented experience with immunohistology technologies is a requirement
• Previous leadership experience.
• You need to be able to work in an organized and timely manner and experience work in multidisciplinary teams.
• Good knowledge in English, both in spoken and written.
• Good knowledge in Microsoft Office programs, such as Word, Excel, Power point and GraphPad Prism.

The following qualifications are preferred (Merits):

• Previous documented experiences of techniques such as CETSA, comet assay, cell synergy experiments are a merit.
• Previous documented experiences working on DNA repair and glycosylases is a merit.
• Previous documented knowledge on clinical trial will be the additional merit.

Bases os assessment

We stress research expertise when assessing applicants.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Department of Oncology-Pathology

Thomas Helleday's Group

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page) Supporting document/certificates, of i.e. working with animals.

Welcome to apply at the latest 2020-11-01.

The application is to be submitted through the Varbi recruitment system.  

Permanent position are initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all