Research Assistant in Immunology and Cell Therapy - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

We are recruiting a motivated and skilled research assistant to join the Cell and Gene Therapy Group (CGTG). The group’s primary research focus is to optimize and clinically adapt strategies to retarget Natural Killer (NK) cells to tumors with limited off-target effects and toxicity profiles. For this purpose, we are currently performing clinical trials where NK cell responses are enhanced and retargeted against tumor cells in patients with Multiple Myeloma (MM).

Your mission

You will be aiming to improve genetic modification strategies for Natural Killer cells, the cytotoxic lymphocytes of the innate immune system. NK cells have inherent mechanisms of resistance to most types of genetic modification strategies. You will be investigating the efficiency of a small inhibitor on improving the NK cell susceptibility to different methods of genetic manipulation, including lentiviral transduction.

On a day-to-day basis you will be required to:

• Organize, plan, execute, analyze and discuss genetic engineering experiments and functional assays of immune cells, and keep up-to-date records
• Organize, prepare, test and optimize common lab reagents, e.g., antibodies and keep up-to-date records
• Assist and work closely with other lab members on experimental work conducted in the laboratory

Type of employment: This is a temporary position for 6 months

Your profile

You must have been granted a Degree of Bachelor within Molecular Biology or Genetics. You must have excellent proficiency of the English language. You must have previous experience of working in a Biosafety level 2 laboratory with primary cell culture, multi-colour flow cytometry, genetic modification of immune cells, lentivirus production, and basic molecular biology techniques such as PCR, western blotting, cloning. A Master’s degree in a relevant discipline and/or advanced knowledge of relevant software such as FlowJo and GraphPad Prism will be an advantage. Prior knowledge of in vitro functional assays, luciferase assay and live cell imaging are meriting.

You are structured, motivated, responsible, approachable, and organized team-player with the ability to work flexibly and independently in a high-paced environment. You should have clear communication and interpersonal skills to cultivate open professional relationships with the group members and be able to discuss data and research questions.  

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

Read more about the Department of Medicine, Huddinge (MedH)

Read more about the Cell and Gene Therapy group

Application

Welcome to apply at the latest December 27, 2023.

The application is to be submitted through the Varbi recruitment system. In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. In addition, please upload a copy of your highest achieved degree and two reference letters.

Want to make a difference? Join us and contribute to better health for all