Postdoctoral Researcher in Single-Cell Genomics and Dosage Compensation at KI

Do you want to contribute to top quality medical research?

The Reinius' laboratory at the Department of Medical Biochemistry and Biophysics conducts research on how our cells handle imbalances in chromosome- and gene-copy numbers, such as the differences in number of X chromosome copies between male (XY) and female (XX) cells and copy number variation common in cancer cells. We are seeking a postdoctoral researcher with deep knowledge and experience in bioinformatic analyses, preferably with documented experience in allele-specific analysis of NGS data from single-cell RNA-seq and single-cell ATAC-seq. We offer a creative and inspiring environment filled with competence and curiosity at the Karolinska Institute, which is one of the world's leading medical universities.

Description of the subject area

Research on how our cells handle imbalances in chromosome- and gene-copy number variation, such as differences in the number of X chromosome copies between men and women or chromosome-copy-number changes in cancer cells. Furthermore, we develop new tools and techniques for RNA/DNA detection and sequencing, including single-cell RNA/DNA sequencing.

Examples of works:

Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq

JC Noble et al. Nature Communications, 2024

https://www.nature.com/articles/s41467-024-52717-4

Multi-layered dosage compensation of the avian Z chromosome

N Papanicolaou, A Lentini, et al. BioRxiv, 2024

https://www.biorxiv.org/content/10.1101/2024.08.20.608780

Elastic dosage compensation by X-chromosome upregulation

A Lentini et al. Nature Communications, 2022

https://www.nature.com/articles/s41467-022-29414-1

Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR

I Smyrlaki, M Ekman et al. Nature communications, 2020

https://www.nature.com/articles/s41467-020-18611-5

X-chromosome upregulation is driven by increased burst frequency

AJM Larsson et al. Nature Structural & Molecular Biology, 2019

https://www.nature.com/articles/s41594-019-0306-y

Your mission

Your mission as a postdoctoral researcher is to perform bioinformatic analyses of NGS data from single-cell RNA-seq and single-cell ATAC-seq with allelic resolution. Data will be made available through experiments conducted at the Department of Medical Biochemistry and Biophysics at the Karolinska Institute. You will conduct independent research within the project's subject area with the goal of publishing the results in leading scientific journals.

Your profile

To be eligible for employment as a postdoctor a phd or a foreign degree deemed to be equivalent to a Swedish phd is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

In addition to the aforementioned requirements for the position:

- PhD or equivalent degree in bioinformatics, biosciences, biotechnology, or related fields, with a strong interest in biotechnological applications.

- Expertise in commonly used programming languages in modern bioinformatics, such as Bash/Shell Scripting, Python, and R.

- Documented work in bioinformatics

- A strong interest in data-driven research and interdisciplinary science, with a focus on practical applications in Life Sciences.

- Strong communication skills in spoken and written English

- Timepoint of availability (we need personnel as soon as possible)

Meritous for the position:

We are looking for a candidate who is ambitious, driven and result oriented. As the position involves working in an international environment, it is essential that you have the ability to work both independently and as part of a team. Strong interpersonal skills and a collaborative mindset are key, along with the ability to build relationships and communicate effectively in an international environment. Emphasis will be placed on personal suitability.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Biomedicum Solna, Karolinska Institutet

https://www.reiniuslab.com/

https://ki.se/en/about-ki/jobs-at-ki/choose-to-work-at-ki-ten-reasons-why

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2025-01-31

The application is to be submitted through the Varbi recruitment system.

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