Research assistant in the development of modified extracellular vesicles

Do you want to contribute to improving human health?

The Department of Laboratory Medicine consists of seven departments within which both research and teaching are conducted. The department is involved in advanced research in both basic and applied research. All departments work in close contact with clinics at Karolinska University Hospital. The department's educational activities contribute to most programs and courses within KI's total educational offerings.

The Division of Biomolecular and Cellular Medicine (BCM) focuses on the use of modified biomolecules, cells and cell products as novel therapeutic agents and the identification and study of suitable biomolecular and cellular targets for therapy and diagnosis.

Currently, we are looking for a motivated and research-minded individual to join our research group to contribute to the development of modified extracellular vesicles for targeted cancer therapy.

Subject description

The Oscar Wiklander research group has expertise in extracellular vesicles (EVs) as diagnostic and therapeutic tools. EVs are small membrane vesicles secreted by all cells and found in body fluids, making them attractive candidates both as drug carriers and biomarkers. We apply synthetic biology engineering strategies to construct and optimize antibody-binding EVs (Fc-EVs) and to isolate and analyze disease-associated EVs from blood and other body fluids.

Your mission

We are looking for an ambitious research assistant with biotechnological expertise to develop the next generation of Fc-EVs. The work includes the design and optimization of bioengineered vesicles with enhanced antibody-binding capacity. The position may also involve the development of methods for isolating extracellular vesicles from bodily fluids, as well as analytical methods to identify the molecular signatures of the diseases they carry.

Your profile

The ideal candidate should be a motivated and team-oriented individual with good English skills, knowledge in the field of extracellular vesicles, and biotechnological expertise. The research will involve laboratory work including cell culture, cloning, flow cytometry, and various techniques in molecular biology.

The candidate must:

• Hold a completed master’s degree in biotechnology or equivalent competence.
• Have documented experience working with extracellular vesicles.
• Have practical experience in cell culture, transfection, and molecular biology techniques.
• Be able to understand and communicate in English in order to work independently.

Merits:

• Experience in design and cloning of plasmids
• Knowledge of antibody-based targeting
• Experience in imaging flow cytometry
• Experience in flow cytometry
• Experience in nanoparticle tracking analysis
• Engineering Degree in Biotechnology

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

Application

Welcome to apply at the latest 18 June.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all