Karolinska Institutet, Dept. of Oncology-Pathology, Research group Lehtiö

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Karolinska Institutet – SciLifeLab/Clinical Proteomics Mass Spectrometry
The position is within the regional and the national core facilities led by Professor Janne Lehtiö, located at the Science for Life Laboratory in Solna. The regional core facility is tasked with aiding users of Swedish universities and industry with mass spectrometry (MS) based proteomics projects. The national facility (SciLifeLab/BioMS) offers infrastructure for biological mass spectrometry (www.bioms.se). BioMS includes three nodes, with the Stockholm node offering services within proteogenomics and chemical proteomics. Combined, the regional and national facilities offer a unique research infrastructure and expertise with focus on MS-based proteomics and proteogenomics. Our robust, highly sensitive techniques allow us to identify and quantify thousands of different proteins within a single sample.

The MS platform is equipped with the latest peptide separation techniques and MS instrumentation including a variety of different high-resolution LC-MS instruments with complementary characteristics. This state-of-the-art instrument platform allows for a wide range of proteomics applications including post-translational modification analysis. The MS-platform facility provides fee-for-service sample analysis as well as support to plan and perform larger in-depth proteomics projects.

The core facility works in close collaboration with Prof. Janne Lehtiö’s research group, where MS-based proteomics methods are constantly developed and applied to studies aiming at improving individualized cancer therapy. This collaboration is a prerequisite for the core facility’s ability to offer services at the forefront of MS based proteomics.

We are now looking for a PhD level research engineer or equivalent to join the team working in the Mass Spectrometry core facility.

Job Description / Duties
The responsibilities accompanying this position include sample preparation, bio analytical work, analysis and reporting of protein/peptide expression, method development, use/optimization of the MS instruments, data analysis and data interpretation. A major aspect of this position involves laboratory work, thus experience in a laboratory is essential. The position also includes coordination of core facility projects as well as working in  collaborative projects including meeting bookings and follow-up. Experience in method development, data analysis and reporting is meriting.

The role also includes reporting analysis results to facility users, taking part of  undergraduate/postgraduate teaching/training and representing the facilities at national and international meetings and conferences.

The research engineer will be part of a research infrastructure, working closely with project scientists, postdoctoral fellows, PhD-students, undergraduate students, and external users/customers within academia and industry. Important aspects of the job include:

  • Preparation of clinical and in-vitro samples for proteomics
  • Experimental analysis of samples by mass spectrometry
  • Compiling and analyzing proteomics data
  • Continuous contact with customers by email and phone

The work involves a combination of flexible and routine tasks and places a great emphasis on independence, initiative, precision, and planning. The position involves a variety of tasks in a stimulating research environment. Nice and helpful colleagues contribute to a good working environment within the group.

A large part of the job may be contact with customers/researchers from a wide range of fields, which is an exciting, interesting and instructive part of the work. The facility/research group is located at the Science for Life Laboratory with spacious and modern facilities.

We are seeking a highly motivated PhD level research engineer for a 1+1 year position to be part of our mass spectrometry core facility.

The successful candidate should have:


  • PhD degree in analytical chemistry, biochemistry, biotechnology or in a related field
  • Extensive hands on experience of laboratory work and ability to follow SOPs daily
  • Practical experience in large scale analytical methods such as mass spectrometry
  • Good knowledge in methods used for analysis of omics data
  • Excellent communication and organizational skills
  • Good knowledge (both speaking and writing) of English


  • Competence/experience in MS-based clinical proteomics research
  • Research experience using MS-based proteomics
  • Hands-on experience with LC and MS instruments
  • Data management and data services
  • Experience in core facility work
  • Experience of purchasing and procurement
  • Strong interests of working in centralized shared research infrastructures

We place great emphasis on personal suitability. To succeed in the role, it is important that the applicant has a personal drive and flexible mind to handle the rapidly developing field of proteomics and the need of custom-based solutions in many projects. The applicant should be responsible, have a great sense of service, appreciate daily, detailed work as well as have the ability to see the big picture. The applicant should be an effective communicator, have good organizational skills, and be able to prioritize at times when the workload is high. The applicant should be able to collaborate with people of different backgrounds and at different levels (both within the group and with users from various disciplines).

Application process
The application is to be submitted in Varbi recruitment system.

Type of employment Temporary position
Contract type Full time
First day of employment 2019-01-01
Salary Månadslön
City Solna
County Stockholms län
Country Sweden
Reference number 2-5792/2018
  • Maria Pernemalm, 070 3030465, Maria.Pernemalm@ki.se
  • Lukas Orre, 073 7047177, Lukas.Orre@ki.se
Union representative
  • Mimmi Shoshan, SACO, 08 5177 54 60
  • Helen Eriksson, OFR, 08 517 762 79
  • Andreas Lundqvist, SACO, 08 517 768 84, andreas.lundqvist@ki.se
Published 24.Oct.2018
Last application date 14.Nov.2018 11:59 PM CET

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