Research Specialist in T cell targeting of leukemic stem cells

Do you want to contribute to top quality medical research?

The Department of Medicine, Huddinge conducts preclinical and clinical research in a variety of areas and undergraduate and graduate education. The department is internationally oriented and consists of seven units with about 40 teams.

Description of the subject area

The Jacobsen lab comprises an international collaborative team focused on understanding at the single cell level the cellular and molecular pathways governing the earliest fate decisions in normal hematopoiesis and how these are dysregulated in hematologic malignancies. This is studied in mouse models, as well as in relevant patients. Key technologies applied towards these research questions include high-throughput DNA and RNA sequencing including single cell analysis, genetic fate-mapping using next-generation-sequencing technology, flow cytometry, mouse genetics and various in vitro and in vivo stem cell assays. The postholder will have the opportunity to lead projects focused on the use of single cell functional assays and genetic fate-mapping.

Your mission

The researcher will drive a project with focus on using T cell receptors to target stem cells in normal and leukemic blood formation. The project is largely focused on studies in mouse models.Applicants are expected to take the lead on a high-profile research project through active pursuit of relevant experiments, and through regular interactions with the group leader and important collaborators.

Eligibility requirements

• To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, and the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.
• The applicant should have a strong track record (including evidence of one or more high impact first author publications) in studies of leukemia in mouse models. This is a requirement to be considered for this position.
• Extensive experience working with the effects of T cell receptors in mouse models of normal or malignant hematopoiesis is required.
• Very good knowledge of spoken and written English is required.

Assessment criteria

It is particularly meritorious that the applicant has shown

• Training in international leading laboratories is a merit as is a background.
• Excellent interpersonal and communication skills, organizational skills to plan experimental benchwork and the ability to work as part of a team as well as independently when required. Ability to stay on top of the relevant research field is an absolute requirement.
• After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top-quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Department of Medicine, Huddinge | Karolinska Institutet

Hematopoietic Stem Cell Biology Group – Sten Eirik W. Jacobsen Lab | Karolinska Institutet

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents:  PhD certificate, resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 2025-02-28.

The application must be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all!