Postdoc positions in single-cell cancer multiomics and/or computational biology

Do you want to contribute to top quality medical research?

Division

Research group

Join us at the department of Oncology-Pathology, Karolinska Institutet. The research group led by Martin Enge is specialized in methodology-driven analysis of patient data, especially in the field of single-cell multiomics. We are a multidisciplinary group with expertise in both dry- and wet-lab methods. We combine cutting-edge basic science with strong ties to the clinic and aim to directly influence future clinical practice.

Duties

Cell types in healthy tissues only take on a finite number of states, since they are generated following a strict developmental program. Cancer cells, however, carry genetic alterations that may remove such constraints, leading to a fundamental challenge: the potential co-existence of genetically distinct clones, each supporting multiple stable cancer cell states.

To understand the effect of subclonal variation in cancer, we have developed a set of single-cell multiomics methods, such as DNTR-seq for joint WGS/mRNA-seq (see: Zachariadis et al. Mol. Cell 2020, Andrews et al. Nat. Methods 2021, Enge et al. Cell 2017). In this project, we are applying the methods to leukemias and solid tumors with a high level of subclonal genetic heterogeneity to understand the general rules of how gene dosage affects expression, as well as longitudinally during treatment to better understand genetic and epigenetic features of treatment persistence.

Your profile

We are looking for 1-2 highly driven scientists, with an interest in pushing the boundaries of single-cell cancer genetics. The candidate should already have a strong scientific record in the form of high-impact scientific publications, and be comfortable with independently pursuing scientific questions. Our projects are multidisciplinary in nature, and the ideal candidates are comfortable with moving outside their field to understand both molecular biology and computational methods. We rely heavily on collaborations with clinicians, which the successful candidate will be expected to manage. Proficiency in written and spoken English is necessary.

We are primarily looking for candidates with the following profiles:

1. A computational researcher with an interest in cancer genetics. The ideal candidate has a strong foundation in computer science/computational biology. Specific experience in analyzing sequence-level data on single cell level, R/Bioconductor and Python/Tensorflow will be useful but is not a requirement.
2. An experimental researcher with an interest in methodologically driven cancer research. Strong track record demonstrating proficiency in molecular biology methods is necessary. Specific experience in cancer genetics or single-cell genomics will be useful but is not a requirement.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system. At the latest 27^th May.

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