Postdoctoral Researcher in Medical Inflammation Research

Do you want to contribute to top quality medical research?

Medical Inflammation Research (https://ki.se/en/mbb/division-of-immunology) is a research group led by Rikard Holmdahl within the division of Immunology and under the department of Medical Biochemistry and Biophysics.  Our main emphasis is on autoimmune diseases, using mouse models for arthritis as a prototype disease. We have positioned major genetic polymorphism causing arthritis and are now investigated their molecular pathophysiologic mechanisms. New diagnostic and therapeutic approaches are developed with the aim to transfer the knowledge into clinical use. The laboratory and the connected animal house is organized for performing the outlined work. Today the research group consists of 2 PhD students and 5 postdocs. In this environment many PhD students and postdocs have been educated and are now in career positions in academia or pharma industry.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a postdoc to join the Medical Inflammation Research group. We suggest a project to analyze the NCF1 mediated regulation and antigen-selection of   B suppressor cells (see Aoun et al JEM 2023). This will involve identification of the B cell VDJ repertoire for B suppressor cells at different tissue locations.

The successful candidate will have:

- Academic qualification in Biology and Health Sciences related fields;

- 2 years recent relevant work experience in a laboratory;

- Experience with laboratory animals (FELASA certificate);

- Experience in Immunology, Molecular Biology, Microbiology

- Fluent spoken and written English skills;

- Well-developed critical thinking skills.

The candidate is supposed to be involved in relevant projects related with Rheumatoid Arthritis. Animal models that mimic the development of this autoimmune disease in humans will be used, mainly mice. The following techniques are also expected: breeding, maintaining and genotyping colonies of mice; immunization of the mice; scoring and accompanying the onset of the disease; collection of various organs and blood; perform flow cytometry in the collected organs; ELISA; microscopy; quantitative real time PCR of selected genes; cell culture; hybridomas production and RNA-seq.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2024-05-16

The application is to be submitted through the Varbi recruitment system.

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