Postdoctoral studies in uncovering novel metabolic targets and differentiation inducing agents in tumors (scholarship) - Hiring in process/Finished, not possible to apply

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The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

Division

The Arsenian-Henriksson Lab conducts research on the MYC family of oncoproteins and network, to uncover their contribution to tumorigenesis, differentiation, metabolism, and apoptosis in different types of cancer. We are a multicultural and dynamic group with many national and international collaborators.

Duties

A highly motivated, skilled, and creative researcher is needed to join our team.

The successful candidate will investigate the impact of MYC in metabolic reprogramming to identify novel metabolic proteins that could be used as potential therapeutic targets. Another project concerns alternative strategies involving MYC to induce differentiation of childhood neuroblastoma. The postdoctoral researcher is expected to take a leading role in experimental design, experimental performance, data analysis, and presentation/publication of the results in manuscripts as well as at conferences. The successful candidate should have experience in writing grant applications and in supervising Bachelor and Master students.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

The Arsenian-Henriksson Lab are looking for an enthusiastic and driven person interested in our area of research and ready to explore new paths for cancer therapeutics.

In addition to the aforementioned requirements, the applicant must:

• Have a high degree of independence but with collaborative mindset
• Work productively in a team, and contribute to a good social and work environment in the laboratory.
• Hold a Ph.D. degree in Biomedical Science and have a solid background in cancer biology
• Have fluency in written and spoken English, it's a requirement

• Be well familiar with standard molecular and cell biology techniques including:

  • Advanced cell culture, drug testing and immunofluoresence
  • Molecular biology techniques including PCR and Western blot
  • Imaging techniques and data analysis
  • Metabolic profiling assays
  • Sample preparation for Lipidomics, Proteomics and RNAseq
  • Lentivirus transduction
  • In vivo studies in mice and immunohistochemistry of tumor samples
  • Making figures using Graph Pad, Biorender etc

Meritorius for the position:

• Previous experience in research on tumor metabolism, differentiation, and/or target identification is a prerequisite.
• Knowledge and experience in MYC and neuroblastoma biology is an advantage.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

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