Postdoctoral Studies in Regulation of Human NK Cell Differentiation (Scholarship) - Hiring in process/Finished, not possible to apply

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Karolinska Institutet, Department of Medicine, Center for Hematology and Regenerative Medicine

We are seeking a highly motivated and ambitious individual to join the research group of Yenan Bryceson as a Postdoctoral Fellow to further elucidate primary immunodeficiency diseases and decipher the molecular regulation of human NK cell differentiation and memory. Our ambition is to develop future research leaders.

Your mission

Previously considered an arm of the innate immune system, recent studies from our group (Schlums, et al., Immunity 2015; Schlums, et al., Blood 2017; Wu et al., Sci Immunol 2018; Holmes et al., Sci Immunol 2021) as well as others have uncovered distinct NK cell differentiation and memory processes. We seek further understanding of NK cell development and immunological memory, which can explain life-threatening primary immunodeficiency disease (PID) syndromes and can be harnessed for cellular immunotherapy of cancer. A successful postdoctoral candidate will be involved in PID diagnostics and exploring novel molecular aspects of human NK cell biology, derived from insights from studies of primary immunodeficiency patients as well as transcriptional and epigenetic analyses. Methods will include advanced flow cytometry and sorting, analyses of chromatin structure and epigenetic modifications, single-cell RNA-seq, genetic manipulation, and functional analyses.

The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers within hematopoiesis and immunity in Europe. The laboratory offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. You can benefit from access to state-of-the-art core facilities at Karolinska Institutet. In the Bryceson group (http://www.ki.se/en/medh/yenan-bryceson-group), you will be working in a very international and interdisciplinary research environment, where collaborative efforts are encouraged.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Qualification requirements

• PhD or MD-PhD degree with previous research experience
• First authorship papers in high-ranking, peer-reviewed journals
• Fluent oral and written communication skills in English

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Skills, and personal qualities

Skills that count in the assessment

Experience in using a variety of molecular biology technologies Experience in using a high-throughput sequencing, transcriptomics, epigenetics Experience working with primary cells Knowledge of lymphocyte biology Knowledge and experience of bioinformatics Personal fit

Personal qualities

Hard-working and driven Organized Self-directed and independent Creative Collaborative, team player

Duties and work tasks

Elaboration of scientific hypothesis, experimental design Flow cytometry analysis and sorting Design and conduct transcriptional and epigenetic analyses Presentation and publication of results

Location: Flemingsberg

The department of Medicine in Huddinge 

Center for Hematology and Regenerative Medicine

Yenan Bryceson group

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all