The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, Alzheimer, bioorganic chemistry, biomaterial, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, immunology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in Neo at Campus Flemingsberg, a biomedical research building, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to the development of a novel biomaterial?

We work in the fields of biotechnology and protein biochemistry, and have invented the first method for producing artificial spider silk fibers. Our main research focus lies in improving the mechanical properties of our fibers, mainly by protein engineering and development of the spinning device, and the project is funded by an ERC consolidator grant. Recently we also discovered how to make recombinant spider silk protein hydrogels that can be used to immobilize enzymes at high density. We have published several articles in high ranked journals (Rising & Johansson ACS Nano. 2021; Schmuck et al. Materials Today. 2021; Andersson et al. Nat Chem Biol. 2017; Kronqvist et al. Nat Commun. 2017; Rising&Johansson. Nat Chem Biol. 2015). The group consists of two PhD students, two technicians and three post docs and one researcher. We are located at Karolinska Institutet, campus Flemingsberg, and at SLU in Uppsala.

Your mission

This project is focused on protein engineering, recombinant expression of silk proteins and functionalized variants thereof in prokaryotic hosts, biochemical and biophysical characterization of the produced proteins and formulation of different materials and mechanical, structural and functional characterization of these. The successful candidate is expected to have a large interest in biotechnology and protein biochemistry and is expected to enjoy practical lab work and independently generate and analyze data. The candidate will supervise doctorial students and master students in the lab. We work in collaboration with other groups and very interdisciplinary, which demands the applicant to be independent, creative, have a positive attitude and be collaborative. The candidate will work primarily at KI campus Flemingsberg, but is also expected to travel to and work in the lab at SLU in Uppsala.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence within the last five years. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent. The applicant should have a doctoral degree in biotechnology, molecular biology, protein biochemistry or similar topic.

Previous documented and extensive practical experience of cloning, expression in E.coli, protein purification and characterization are required. Previous experience of using bioreactors and FPLC systems for protein production and purification is meritous, as is previous experience of biophysical analyses of fibrillating recombinant proteins. The successful candidate is expected to have a strong drive to pursue research, have published in respected international peer-reviewed journals, be organized and structured and have an ambitious and innovative attitude. The project is cross-disciplinary and pursued in collaboration with several research groups, and good collaborative skills are necessary. Emphasis will be put on personal skills in the evaluation process. Very good ability to speak and write English is a requirement.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

The position is for one year with the possibility of extension.

Location: Flemingsberg & Uppsala

https://ki.se/en/bionut/spider-silk-biology-for-biomedical-applications-anna-rising

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100%
City Huddinge and Uppsala
County Stockholms län
Country Sweden
Reference number STÖD 2-4960/2021
Contact
  • Anna Rising, Research group leader, +46-709-74 48 88
  • Thomas Tinglöv, Head of administration, +46-8-524 835 49
Union representative
  • Anders Lindholm, OFR, +46-8-524 810 12
  • Henry Wölling, SEKO, +46-8-524 840 80
Published 12.Nov.2021
Last application date 03.Dec.2021 11:59 PM CET
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