Do you want to contribute to top quality medical research?

Our research group (PI: Eduardo J Villablanca) provides a unique opportunity to work in the field of mucosal immunology and regenerative medicine particularly in the context of inflammatory bowel disease (IBD) and how boosting regeneration could be exploited as a novel therapeutic opportunity for IBD. We offer a highly interactive and innovative research platform to work at the interface using both preclinical models and clinical samples using cutting edge technologies such as patient derived organoids, drug screening, single cell and spatial transcriptomics profiling. Here, you get the opportunity to contribute to the high-quality research at an truly international environment.

Your mission

One of the main goals of Villablanca Lab is to better understand the damage induced cues at the intestinal barrier and how to exploit them for tissue repair with specific emphasis on promoting intestinal regeneration for diseases such as IBD and the same time minimize the risk of tumorigenesis. The project will be performed in close collaboration with Dr. Michael Sundstrom group (at Center for Molecular Medicine, KI) as a part of the SGC -KI. Dr. Villablanca is an internationally recognized leader in the field of Mucosal Immunology at intestinal barrier. The candidate will be part of a research program that integrate experimental models, patient material, ex-vivo patient derived organoids and cutting-edge technologies (spatial and single cell transcriptomics) to understand how intestinal homeostasis is maintained and how breakdown in these processes might lead to IBD or CRC.

Your profile

The applicant should have a PhD equivalent to Swedish doctoral degree in the field of Regenerative and/or Cancer Biology. The candidate should also have a minimum of 4-5 years of relevant post-doctoral experience carrying out high quality research with specific emphasis on intestinal regeneration and tumorigenesis. The candidate must have extensive experience in using intestinal organoid models from both mice and humans as well as using in vivo experimental models of tissue regeneration and tumorigenesis. Experience in dissection, isolation and in vitro culture of intestinal epithelial cells, immune cells, stromal cells and co-culturing of multiple cell types from mucosal tissues is a requirement as well as having experience with molecular biology such as experience in cloning, expression of genes not only in primary cell lines, but also in organoids. Experience in gene manipulation methods such as CRISPR/Cas9 in organoids would be an added advantage. Since the projects involve unbiased transcriptomics approaches, the candidate must have experience in performing 10X single cell RNAseq and spatial transcriptomics approaches. As work will be done involving a team of multidisciplinary scientists, excellent communication skills are essential and proven ability to work in multidisciplinary teams. Fluency in both oral and written English is necessary. Documented ability to analyze and present results orally and written is important as well as the ability to generate new ideas and innovate. It is expected that the candidate would contribute towards supervision of students and other researchers, with ambitions to become a primary supervisor and develop a related independent line of research by obtaining external long-term funding.

A person is eligible to be appointed Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after the defense of his or her doctoral thesis.

Bases os assessment

We stress research expertise when assessing applicants.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group  of Dr. Eduardo Villablanca

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Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The application is to be submitted through the Varbi recruitment system.  

Permanent position are initiated by a six months trial period.


Want to make a difference? Join us and contribute to better health for all

Type of employment Permanent position
Contract type Full time
First day of employment omg
Salary Månadslön
Number of positions 1
Working hours 100 %
City Stockholm
County Stockholms län
Country Sweden
Reference number STÖD 2-2066/2021
Contact
  • Eduardo J. Villablanca, +46 736282289
Union representative
  • Bruna Gigante, SACO, bruna.gigante@ki.se
  • Afsar Rahbar OFR, Afsar.Rahbar@ki.se
  • Louisa Cheung, SACO, Louisa.Cheung@ki.se
Published 27.Apr.2021
Last application date 12.May.2021 11:59 PM CET

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