The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, Alzheimer, bioorganic chemistry, biomaterial, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, immunology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in Neo at Campus Flemingsberg, a biomedical research building, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

Are you interested in learning more about B cells in health and disease? Join us on this exciting KAW project!

Division
The research group of Dr. Qiang Pan-Hammarström works on the molecular mechanism of immunoglobulin gene diversifications, genetics of primary immunodeficiency and B-cell lymphomagenesis. The research laboratory is located at campus Flemingsberg. For more information about the group, please see https://ki.se/en/bionut/research-group-qiang-pan-hammarstrom

Duties
The selected two top postdoctoral fellow candidates will work on a Knut and Alice Wallenberg Foundation funded project entitled “Developmental trajectories for human B cells” and will be supervised by Dr. Qiang Pan-Hammarström at Karolinska Institutet (KI). The project will be conducted in close collaboration with three additional research groups led by Drs. Petter Brodin, Lennart Hammarström and Hong Qian respectively.

The main tasks for the successful candidates are:


1) Characterization of B-cell subsets from primary and secondary lymphoid tissues from normal individuals using unbiased single-cell approaches

2) Identify regulatory modules that drive B-cell differentiation and to model this process in vitro by using inducible pluripotent stem cells and CRISPR-based screening.

3) Identification of developmental or regulartory defects in B cell related disorders such as primary immunodeficiency, B cell malignancies and infectious diseases such as COVID-19

Qualifications
We are seeking a highly skilled and motivated candidate who are interested in applying new technologies and tools for understanding the mechanisms underlying human diseases and for development of novel therapies for patients. The applicant should have been awarded a PhD or equivalent degree in medicine, stem cell biology, immunology, biotechnology, molecular biology, infectious disease or areas relevant to the announced position. He/she should have achieved the corresponding scientific competence, with first-authored publications in internationally leading journals in the corresponding fields. Extensive research experience in one of the areas is required: iPSC cell differentiation, single cell sequencing data analysis, B cell receptor sequencing or CRISPR based screen. The applicant must be able to work productively via collaborative interactions with team members. Furthermore, the candidate should possess excellent communicating and writing skills in English.

Bases of assessment
We stress scientific excellence and potential when assessing applicants. The applicants’ track record based on curriculum vitae and bibliography will be assessed. Evidence for independence, innovation and the capacity to work and publish in a multidisciplinary environment is weighted in ranking the applicants. Reference letters will be requested from the PhD supervisor(s) and considered from selected candidates.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Flemingsberg

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Two recommendation letters, including at least one from the PhD supervisor

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Reference number STÖD 2-732/2021
Contact
  • Qiang Pan-Hammarström, Professor, +46-8-524 835 92
  • Thomas Tinglöv, Head of administration, +46-8-524 835 49
Union representative
  • Anders Lindholm, OFR, +46-8-524 810 12
  • Henry Wölling, SECO, +46-8-524 840 80
  • Chandrashekar Bangalore Revanna, SACO, +46-73-083 98 85
Published 15.Feb.2021
Last application date 01.Mar.2021 11:59 PM CET

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