Postdoctoral Researcher in Epigenomics of Atherosclerosis - Hiring in process/Finished, not possible to apply

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

The position will be placed in the laboratory of Professor Eckardt Treuter which conducts pre-clinical research at the crossroads between epigenomics, metabolism, inflammation and disease. The laboratory is located at the Department of Biosciences and Nutrition, an excellent international research environment performing research in key areas of biomedical science.

https://ki.se/en/bionut/epigenetic-mechanisms-underlying-metabolic-inflammatory-diseases-eckardt-treuter

Your mission

This postdoc project aims to characterize the function of corepressors in atherosclerosis, with an emphasis on epigenetic alterations in macrophages and hepatocytes that potentially link type 2 diabetes and liver fibrosis/steatosis to the development of cardiovascular diseases.

 Specific duties will include:

• Handling, manipulation and characterization of atherogenic mouse models (crossed with conditional corepressor knockouts in macrophages vs. hepatocytes).
• Design experimental mouse procedures and write ethical applications
• Complementary in vitro analysis (mouse, human macrophages)
• Generation and analysis of ChIP/ATAC/RNA-sequencing data
• Preparation of manuscripts and grant applications.
• Organization of laboratory routines
• Supervision of undergraduate and PhD students
  
  

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Ph.D. or equivalent in a relevant discipline such as molecular medicine, molecular biology or physiology. Prior qualifications (e.g. a Felasa B certificate) and solid experience in designing and deeply characterizing transgenic mouse models, metabolism, inflammation, tissue crosstalk, liver and macrophage biology is required. Experience in transcriptional coregulator biology and analysis, genomic and epigenomic profiling, virus delivery systems, in vitro culture of cell lines and primary tissues, including bone marrow-derived macrophage isolation, is a plus.

We are looking for an excellent team player with interpersonal skills, organized, efficient, and flexible in dealing with unpredictability and changes. Emphasis will be placed on personal suitability.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location:  KI South Huddinge (Flemingsberg)

https://ki.se/en/bionut/epigenetic-mechanisms-underlying-metabolic-inflammatory-diseases-eckardt-treuter

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all