Do you want to contribute to top quality medical research?

Description of Research Group and Work place.

The position will be placed in the Biomedicum, one of the most modern research building in Europe hosting a large part of the experimental research at Karolinska Institutet’s Campus Solna. The candidate will work within the groups of ‘Cellular Metabolism’ headed by Assoc. Prof. Erik Norberg and ‘Protein Degradation Pathways’ headed by Assoc. Prof. Helin Norberg.

Our research groups includes scientist from various disciplines working as a team to gain new knowledge. We undertake a multi-disciplinary approach including systems level investigation of autophagy and metabolism. Beyond generating mass spectrometry data on quantitative proteomics and metabolomics, we also generate genomic and transcriptomic data, which are used together with experimental wet-lab data to bring new insights into cancer biology. 

Please see the following references as examples:

Br J Cancer. 2020 Sep;123(7):1164-1177. (PMID: 32636467)

Autophagy. 2019 Sep;15(9):1558-1571. (PMID: 30821613)

Cell Reports. 2017 Jun 13;19(11):2289-2303. (PMID: 28614715)

We now need to strengthen our groups with a computational Biologist/Bioinformatician within the field of multi-omics data analysis and cancer research.

Your mission

We are looking for an outstanding computational biologist/Bioinformatician scientist with experience of analysis of omics data. The position requires solid expertise in genomics, transcriptomics, proteomics and/or metabolomics  

The candidate will work on integrative and translational analysis of multiple levels of omics data derived from cell lines, xenografts, human tumors compared to normal healthy tissues. 

The focus will be on analyses and interpretation of both complex in-house generated and public domain data (incl. The Tumor Genome Atlas and Cancer Cell Line Encyclopedia).

This includes applying established data analysis steps as well as to explore and develop new strategies for the analysis of quantitative biological data.

Experimental design and statistical analysis of the quantitative data are important components of the work. It is expected from the applicant to be acquainted with software and programming languages related to omics data analysis. In addition, enabling omics datasets to be public is important by building and maintaining databases. 

The position offers a great possibility for interaction with scientist across different disciplines.

The employment is a two year (1 + 1) position with a possibility to become a permanent position.  

Your profile

* PhD in bioinformatics, computer science, mathematical statistics or in biology/medicine but with strong practical experience in computational biology. 

* Documented experience (preferably as publications in international peer-reviewed journals) in bioinformatics, including experience with NGS, MS proteomics or metabolomics and bioinformatics algorithms.

* Working experience in systems biology/medicine, large-scale data analysis, integration and visualization.

* Programming/coding experience in one or more platforms: R, Matlab, Python or C++.

* Knowledge in statistical methods

* An understanding of cell- and molecular experimental methods.

* Good communications skills in English.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna, 

Application

An application must contain the following documents in English:

  1. Curriculum vitae, describing qualifications and previous training.
  2. A complete list of publications.
  3. Provide a motivation letter including career goals, relevant experience for the project etc. (no more than one A4 page).
  4. Reference letters from at least two previous employers and their contact information.
  5. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances.
  6. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline.)

Welcome to apply at the latest 2020-11-20

The application is to be submitted through the Varbi recruitment system.  

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment Upon agreement
Salary Monthly salary
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number STÖD 2-4465/2020
Contact
  • Erik Norberg, erik.norberg@ki.se
Union representative
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Gunnel Brolin, OFR, 08-524 810 63
  • Göran Engberg, SACO, 08-524 867 17
Published 23.Oct.2020
Last application date 20.Nov.2020 11:59 PM CET

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