Do you want to contribute to top quality medical research?

The position is in the Rare Diseases research group. We study genetic disorders on a molecular level in order to understand disease mechanisms and apply new knowledge to genetic diagnostics. We work in a modern laboratory at the Bioclinicum building situated within the grounds of the Karolinska University Hospital, Solna. Several group members also work in the Department of Clinical Genetics at the hospital, the largest clinical genetic department in Sweden with 90 employees working with genetic diagnosis and counseling. We also work closely with the Science for Life Laboratory in Solna, and thus have access to massively parallel DNA sequencing (MPS) with all available technologies. We are currently developing in vitro and in vivo modeling assays to evaluate genetic mutations detected in patients

Your mission

We are looking for a motivated person with a background in molecular and developmental biology. The successful selected applicant will be involved in analyzing the function of new candidate genes and mutations in non-coding DNA regions as well as small non-coding RNAs that might be responsible for hereditary disorders (syndromes with skeletal malformations and childhood cancer predisposition) in patients and families that are counseled in our clinic. The selected applicant will help to establish robust techniques to investigate causes of congenital disorders and their association with childhood cancer predisposition. Experience in bioinformatics, cellular models with culturing and analyzing primary cells, zebrafish and mice experimental models is therefore desired. This project provides the opportunity to participate in a translational research project that will have direct clinical impact.

Your profile

A degree within the area of biomedical research or corresponding area is required.
We are seeking a new group member with a broad range of interests and expertise in the following key areas:

1) Bioinformatic analysis of DNA and RNA sequence data 
2) Basic and advanced cell culture, including fibroblasts
3) Image acquisition and analysis: Expertise in immunofluorescent and confocal microscopy, time-lapse imaging, image processing and analysis, including statistical analysis.
4) Molecular Biology/Cell Biology: Knowledge in basic molecular techniques specifically molecular gene cloning, in vitro mRNA synthesis and gene expression assays including PCR, RT-PCR, and qRT-PCR, as well as Western Blot analysis.
Applicants should have prior experience/training in these model systems/areas. The applicant will be evaluated based on education and previous experience, relevance for the project, motivation, problem solving skills, and cooperative ability. Personal suitability is also an important criterion.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

Application

Welcome to apply at the latest 5 April 2020

The application is to be submitted through the Varbi recruitment system.  

Permanent position are initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-1495/2020
Contact
  • Giedre Grigelioniene, Docent, giedre.grigelioniene@ki.se
  • Ann Nordgren, Adj.Professor, ann.nordgren@ki.se
Union representative
  • Virpi Töhönen Saco, virpi.tohonen@ki.se
  • Elisabeth Noren-Krog, OFR, elisabeth.noren-krog@ki.se
Published 20.Mar.2020
Last application date 05.Apr.2020 11:59 PM CET

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