Do you want to contribute to improving human health?

Division
The Lendahl laboratory is interested in the Notch signaling pathway in various organ systems and how dysregulated Notch signaling leads to cancer. We use several different approaches to study Notch signaling, including in vivo models and various cell and molecular biology technologies, including cell culture systems and reporter assays for monitoring Notch downstream signaling activity.

Duties
We are seeking a highly motivated and enthusiastic researcher with a strong background in Notch signaling. The research project will focus on the study of the downstream aspects of Notch signaling and how Notch signaling can be modulated by pharmacological approaches. Reporter assays recording the level of Notch signaling will be used to screen libraries of small compounds in a robotized high throughput fashion.

The project will also involve cell culture-based assays of various aspects of Notch signaling as well as in vivo analysis in mouse models. The successful applicant will be responsible for setting up and organizing the project and supervising direct reports. The project involves extensive collaboration with industry, so background knowledge in industrial collaborations will be crucial.

Entry requirements
The successful applicant should hold a PhD in Molecular Biology with a strong publication record in the area of Notch signaling and at least four years of previous postdoctoral experience. The applicant must have extensive training in a broad spectrum of techniques to monitor and modulate Notch signaling, both in vitro and in vivo, including transgenic mouse technology, immunohistochemistry, qPCR analysis, ChIP-seq analysis, cloning, FACS, genome editing (CRISPR/Cas9) and small compound screening.

The applicant must also be proficient in establishing reporter assays for high throughput screening of small compound libraries and in handling and analyzing small compound libraries. The applicant must be fluent in English (both spoken and written). Basic knowledge of German is a plus, as the project is a collaboration with a Germany-based company.

The successful applicant must have a strong problem-solving analytical ability as well as being flexible and well structured. A person is eligible to be appointed Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence.

Meriting
Prior experience working with Notch signaling, reporter assays in a high throughput format and analysis of Notch signaling in mouse models is a merit.

Bases of assessment
We stress research expertise when assessing applicants.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Application

An application must contain the following documents in English: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio).

Welcome to apply at the latest 2020-04-02

The application is to be submitted through the Varbi recruitment system.  

Permanent position are initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all

Type of employment Permanent position
Contract type Full time
Number of positions 1
Working hours 100 %
City Flemingsberg
County Stockholms län
Country Sweden
Reference number 2-1403/2020
Contact
  • Urban Lendahl, professor, Urban.Lendahl@ki.se
Union representative
  • Biborka Bereczky Veress, SACO , 46 70-173 85 75
  • Elisabeth Valenzuela, SEKO , 46 8-524 863 53
  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
Published 19.Mar.2020
Last application date 02.Apr.2020 11:59 PM CET

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