The Department of Laboratory Medicine consists of 7 divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic scientific, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet. The department of Laboratory Medicine is tightly connected with clinical researchers and healthcare teams at several departments of the Karolinska University Hospital, which allows for translational research involving clinical material and the potential to bring new therapies from bench to bedside.

The facilities at Laboratory Medicine offer state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. The vision of the Department is to conduct research to promote human health. This research often leads to new diagnostic methods, clinical practices or to new treatments.

The division of pathology and the research group
The Division of Pathology is one of the divisions within the Department of Laboratory Medicine in Huddinge. Our research spans from the whole-body level down to specific tissues and organs at the molecular level. Research is conducted in close collaboration with other departments at KI and also the Karolinska University Hospital.

A position of Senior Lab Manager is available within the research group headed by Dr. Jaakko Patrakka. The group focuses on renal glomerulus biology and diseases.

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney

Senior Lab Manager duties
We are seeking a Senior Lab Manager to become a central organizational figure within our division. At the division of Pathology, we have a number of research groups with different backgrounds who need to work together effectively and efficiently. The Lab Manager will be essential in the process of designing a transparent environment.

The Lab Manager role will be to coordinate the everyday running of the lab and to facilitate interactions between researchers at the division. The Lab Manager will be responsible for ensuring a smooth operation of the lab including taking charge of practicalities such as ordering, risk assessments, biosafety and work environment.

The Lab Manager will also be responsible for introducing new and visiting researchers in the lab environment including training in laboratory techniques, instrument function, lab routines and SOPs critical to the running of the lab. The Lab Manager will have significant teaching, mentoring and research roles, being a central figure in numerous ongoing and future research projects. The Lab manager will be active in seminars, group meetings and other events organized by the division.

Who are you?
We are seeking a highly motivated, authoritive person with a broad skill set. To enable the person to fit in with our research interests we seek a candidate with the following skills/qualifications:

• PhD qualification in Biomedical Sciences

• Proficiency in English is required. Knowledge of Swedish and additional lanuages will be advantageous to work in a multi-cultural environment

• Animal surgery skills are an absolute requirement. These include laparotomy, unilateral obstruction, renal pedicle clamping, STZ model, intravenous and IP injections, oral gavage, dissections, saphenous and mandibular vein blood collections and in vivo GFR measurement.

• Demonstrated skills in independent managing of colonies of laboratory mice and rats; including mating, genotyping, cataloging and record keeping. The applicant needs to be familiar with the Swedish animal welfare legislature, FELASA certification is required, FELASA C/advanced course FUNCTION B preferred.

• Experience with a broad range of lab techniques with a focus on the following areas: Cell culture techniques, RNA sequencing, qPCR, Western blotting, immunohistochemistry/immunofluorescence, in situ hybridization

• Microscopy, including confocal and multi-photon microscopy of cells, tissues and organs

• Multidisciplinary approaches, shown ability to embrace multi-disciplinary research projects

• Project management experience

• Experience in mentoring students

• Experience in establishing new methods

• Excellent problem solving abilities

The candidate should appreciate problem solving and development of new technologies required to bring the project forward but also demonstrate an ability to complete projects within a defined time frame. Independence is essential, however not sufficient as the candidate must also be able to contribute as a team player and collaborate with other scientists.

Applicants who have a clinical background within nephrology is given special consideration.

Application process
The application must contain the following documents:

1. A complete curriculum vitae with cover letter and a summary of current work and history

2. A complete list of publications

3. Names and contact details of three references who are familiar with the applicant’s recent research and training.

The application is to be submitted on the Varbi recruitment system.

Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-589/2020
  • Jaakko Patrakka, ,
Union representative
  • Carina Eklund, OFR, 08-585 826 65
  • Emilie Hultin, Annica Lindkvist, SACO, 08-524 832 86, 08-524 837 46
  • Henry Wölling, SEKO, 08-524 840 80
Published 03.Feb.2020
Last application date 01.Mar.2020 11:59 PM CET

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