Karolinska Institutet, Institutionen för fysiologi och farmakologi, Biomedicum 5D

At the Department of Physiology and Pharmacology (http://ki.se/fyfa_english) we teach and conduct research in Physiology, Pharmacology, Anaesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students.

 

Background

The research at our Inflammation Physiology lab aims to understand the pathophysiological mechanisms of atherosclerosis, the underlying pathology for myocardial infarction and stroke and hence responsible for most deaths worldwide. We have identified the importance of neutrophils as key drivers of vascular inflammation, unveiled important processes these cells set off, and designed preclinical intervention strategies aimed at halting these processes (e.g. Silvestre-Roig, Nature, 2019; Paulin et al., Circulation, 2018; Alard et al., Sci Transl Med, 2015). In recent years we have learnt that acute cardiovascular events peak at a certain time of day and our studies have revealed circadian leukocyte recruitment as possible cause for such pattern (Winter et al., Cell Metab 2018). We have now teamed up with Novo Nordisk to map changes in circadian gene and protein expression in depth to develop innovative strategies of chronopharmacological intervention. 

 

Duties

We are looking for a postdoctoral researcher who will employ advanced bioinformatics of transcriptomic and proteomic data sets to map changes across tissues over the day.   

 

Entry requirements

Qualified for the position is one who has obtained a doctorate or has equivalent scientific competence.

 

Qualifications

The applicant should have a PhD degree with focus on bioinformatics and have an interest in physiology, inflammation, and circadian biology. Basic understanding in systems biology and analysis of large scale data sets are required. Coding skills (e.g. R, python), the ability to set up pipelines, and the ability to work independently are needed. Taking own initiative to move this project forward is desired. Basic understanding in simple wet lab techniques (e.g. RNA extraction) is a plus. Furthermore, good communication skills and good proficiency in spoken and written English are necessary.

 

Application process

An application must contain the following documents in English:

  1. Curriculum vitae and qualifications,
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted on the Varbi system.

Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Anställningsform Visstidsanställning längre än 6 månader
Anställningens omfattning Heltid
Tillträde By agreement
Löneform Monthly payment
Antal lediga befattningar 1
Sysselsättningsgrad 100 %
Ort Stockholm
Län Stockholms län
Land Sverige
Referensnummer 2-303/2020
Kontakt
  • Oliver Soehnlein (Head of Section) , oliver.sohnlein@ki.se
Facklig företrädare
  • Niklas Andersson, OFR, niklas.andersson@ki.se
  • Bo Rydqvist, SACO, 08-524 872 67
Publicerat 2020-01-16
Sista ansökningsdag 2020-02-15

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