Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group
Applications are invited for a PhD student position in Gonçalo Castelo-Branco ́s group (ki.se), Karolinska Institutet, Stockholm, Sweden. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), within the Unit of Molecular Neurobiology. The Unit of Molecular Neurobiology has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment.

The doctoral student project and the duties of the doctoral student
Our research group has performed single/nuclei cell RNA-Seq and identified several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019). Our findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought. The overall aim of the doctoral project is to investigate whether the new identified transcriptional states within the oligodendroglia lineage during development and in disease have functional significance.

What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents
Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities

We are looking for a highly motivated, driven, inquisitive, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidates should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory. The applicants must have a Master degree in Biomedical Sciences, Molecular Medicine or Neuroscience, or similar, and it is desirable to have previous research experience in a multidisciplinary international environment in areas such as:

  • culture of rodent oligodendroglia cell culture
  • confocal and live-cell time lapse microscopy
  • immunofluorescence (immunohistochemistry and immunocytochemistry) and in situ hybridization (such as RNASCOPE)
  • FACS
  • work with rodents (including EAE mouse model of MS), with according certification
  • epigenetics and transcription

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents:

- A personal letter and a curriculum vitae (Swedish or English)
- Degree projects and previous publications, if any (Swedish or English)
- Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

 All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Type of employment Doktorandplats
Contract type Full time
Reference number 2-5990/2019
Contact
  • Gonçalo Castelo-Branco, 08-524 879 36
Published 29.Nov.2019
Last application date 13.Dec.2019 11:59 PM CET

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