Karolinska Institutet, Department of Cell and Molecular Biology, Frisén

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

Research group
The position is placed in the research group of Jonas Frisén at the Department of Cell and Molecular Biology, Karolinska Institutet. We study cell generation during development and in the adult body, with special interests in the central nervous system, heart, immune system and prostate. We are interested in the extent, lineage relationships and functional role of cell generation in physiological and pathological situations in mice and humans.

The doctoral student project and the duties of the doctoral student

We are seeking a highly motivated and enthusiastic doctoral student to study cell lineage evelopment in the mouse nervous system. The approach uses genetic barcoding in embryos and adult mice, flowcytometry, RNA-sequencing, bioinformatics, genetic modifications and phylogenetics, combined with tissue analysis by for example immunohistochemistry. We aim to delineate cell lineages and the molecular mechanisms that govern cell diversification in the nervous system

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

  • Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities
We expect you to be a very creative person with excellent communication skills and abilities to collaborate and work in a highly dynamic international research team. You must have experience with mouse brain dissection and dissociation,  a laboratory animal science certificate for working with mice in an animal facility, preparation of RNA-seq libraries using 10x Chromium and/or Smart-Seq2 and analysis of single cell RNA-seq data for cell type identification, genetic barcode extraction and lineage reconstruction (using e.g. Python). Furthermore, it is highly valued if you have experience of injections in the nervous system of mice.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents:

  • A personal letter and a curriculum vitae (Swedish or English)
  • Degree projects and previous publications, if any (Swedish or English)
  • Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
  • Documents certifying your general eligibility (see A above)
  • Documents certifying your specific eligibility (see B above)

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

KI uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.


All applicants will be informed when the recruitment is completed.

Type of employment Doktorandplats
Contract type Full time
Reference number 2-6035/2019
  • Jonas Frisén, jonas.frisen@ki.se
Union representative
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75
  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
  • Elisabeth Valenzuela, SEKO, 08-524 863 53
Published 08.Nov.2019
Last application date 28.Nov.2019 11:59 PM CET

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