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The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several divisions that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.
Division
Research at the division of Rheumatology is truly translational with excellent access to patient material and active clinicians, biologists and epidemiologists. The research spans a wide range of subjects, covering areas as diverse as clinical rheumatology, antibody biology, basic T cell biology, inflammatory mechanisms and more.
The postdoctoral studies will be performed jointly in the labs of Associate professor and clinical dermatologist Liv Eidsmo, and Assistant Professor Carmen Gerlach (www.gerlachlab.com).
Research in the Eidsmo lab focus on the role for resident T cells during homeostasis and immunopathology in the human skin. We have recently defined functional subsets of resident T cells and how these cells interact within the natural microenvironment during the inflammatory skin diseases psoriasis and vitiligo. Currently, the lab heads a mechanistic study of a global clinical trial, investigating if resident T cells can act as biomarkers of remission of psoriasis.
Research in the Gerlach lab is directed at understanding basic cellular and molecular principles governing T cell responses to acute infections and cancer. We strive to understand mechanisms underlying the generation, maintenance and consequences of the heterogeneity within the T cell immune response, with a special focus on CD8 T cells.
The two labs are collaborating closely, hold joint labmeetings and journal clubs, and are physically located in close proximity to each other at the Center for Molecular Medicine, CMM at the Solna Campus of the Karolinska University Hospital. CMM has computational infrastructure, and provides a local bioinformatics hub/network where bioinformaticians from all research groups within CMM can exchange ideas and expertise.
Duties
The postdoc will be collaborating with wet-lab scientists in both labs. The postdoc is expected to plan, execute and interpret bioinformatic analyses of primarily single-cell RNA sequencing data obtained from T cell receptor and mRNA sequences through Illumina sequencing of libraries obtained through the 10x Genomics workflow. In addition, the postdoc is expected to perform bioinformatic analyses of other datasets available in the labs. There will also be possibilities to analyze epigenetic data, primarily obtained using the ATAC-Seq platform. The postdoc is expected to carefully document the analyses, and to communicate the results within and outside of the research group. The postdoc is expected to work both independently, and as a collaborative and helpful team member. The duties furthermore include actively taking part in research meetings, contributing to the well-functioning of the local research environment, and assisting/training/supervising other lab members in minor computational analyses.
An employment application must contain the following documents in English or Swedish:
Welcome to apply at the latest
The application is to be submitted through the Varbi recruitment system.
Type of employment | Temporary position |
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Contract type | Full time |
Number of positions | 1 |
Full-time equivalent | 100 |
City | Stockholm |
County | Stockholms län |
Country | Sweden |
Reference number | 2-4902/2019 |
Contact |
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Union representative |
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Published | 30.Sep.2019 |
Last application date | 27.Oct.2019 11:59 PM CEST |