Karolinska Institutet,

Olov Anderssons research group, part of Department of Cell and Molecular Biology (CMB),  recently moved to Biomedicum. A new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum will house approximately 1,600 researchers and other personnel and allow expensive equipment to be shared and utilized more effectively.

Division and Duties
We are seeking a highly motivated and enthusiastic postdoctoral fellow to study how small molecules can promote regeneration of beta-cells in zebrafish. In an ERC-funded lab the succesful applicant will be using chemical-genetic screening techniques in zebrafish to identify compounds, genes and signalling pathways that can promote β-cell regeneration. For examples of how the research can be conducted, see:

Andersson et al., Cell Metabolism:

http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00188-X

Lu et al., The EMBO Journal:

http://emboj.embopress.org/content/early/2016/08/11/embj.201592903.long

Liu et al., Diabetes:

http://diabetes.diabetesjournals.org/content/early/2017/09/30/db16-1587

The present project will extend our initial studies using pharmacology to genetics in zebrafish, as well as to studies in the mouse. The studies will include assessing neogenesis/differentiation and reprgramming to beta cells, and how such cellular changes affect glycemia.

The zebrafish are amenable to efficient transgenesis and high-resolution imaging. We will make use of these properties to generate transgenic/mutant zebrafish for single-cell analysis of phenotypes. The successful applicants will have a strong background in cell and molecular biology or biochemistry, and keen interest in beta-cell regeneration using model organisms.

Funding for the position is available for an initial period of two years.

Entry requirements
We are looking for independent and driven candidates who have at least one first-name publication in a peer-reviewed journal. A documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.

The successful applicants may have experience in one or several of the following techniques/models:

  1. Molecular, cellular and biochemical techniques, e.g. cloning, Q-PCR, and immunohistochemistry
  2. Drug screening
  3. Bioinformatics
  4. Metabolism/diabetes research in mouse models
  5. Organoid cultures
  6. Zebrafish as a model system

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A cover letter stating the motivation to apply and key skills that match the profile (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Reference number 2-1952/2019
Contact
  • Olov Andersson, olov.andersson@ki.se
Published 26.Mar.2019
Last application date 26.Apr.2019 11:59 PM CET

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