Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology

Division
Division MTC offers an opportunity for postdoctoral research studies in Tumor Biology. The research of the Arsenian Henriksson group is focused on the childhood cancer neuroblastoma. Today, neuroblastoma ranks as the most common and aggressive solid tumor in infants with 90% of cases diagnosed by age 5. Amplification of the MYCN oncogene is found in approximately 30% of all neuroblastoma cases and is associated with poor prognosis and chemotherapy resistance.

Duties
The group has previously demonstrated that MYCN inhibition leads to metabolic alterations and results in lipid accumulation in neuroblastoma cells (Zirath et al., PNAS 2013). The aim of the current project is to study how MYCN controls the energy metabolism in neuroblastoma using a combination of proteomics, metabolic profiling and gene expression dataset analysis. (Cell Reports 2016 and Dzieran et al., PNAS 2018.)

Entry requirements
We are looking for a highly motivated, creative, responsible researcher who has the capacity to work independently as well as in a team. A PhD degree awarded in cancer biology with experience in neuroblastoma and metabolism is required. The applicant should have a strong background in molecular cell biology and cancer metabolism. Practical experience of standard cell biology techniques, including advanced real time metabolic functional assays in mammalian cells. Experience of design of in vitro and in vivo studies; analysis of proteomic and genomic data and expert skills in statistical evaluation of data. The successful candidate needs to have experience of design and analysis of in vivo as well as in vitro drug studies. Previous experience in training master students is an advantage.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An employment application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Reference number 2-434/2019
Contact
  • Marie Arsenian Henriksson, 08-52486678
Union representative
  • Niklas Andersson, OFR, niklas.andersson@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Daisy Hjelmqvist SACO, daisy.hjelmqvist@ki.se
Published 22.Jan.2019
Last application date 04.Mar.2019 11:59 PM CET

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