Postdoctoral Researcher in proteomics - Hiring in process/Finished, not possible to apply

Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 81 PhD students, 77 postdoctoral researchers and 32 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations

Division
The research group of Sir David Lane, FRS, is located at Karolinska Institutet in Solna and the SciLifeLab. The group consists currently of a PhD student, a lab manager, three postdocs, one assistant professor, two senior scientists, and a professor.

Our group works with all aspects of molecular biology to develop cancer treatment strategies. We focus particularly on the chemistry and biology of tumour suppressor proteins in the p53 pathway and how their central role in damage control and cell cycle regulation can be exploited therapeutically. Our lab includes state-of-the-art mass spectrometry, microscopy, and cell sorting facilities and closely collaborates with Sonia Laín’s chemical biology group at the Department of Microbiology, Tumor and Cell biology, KI, providing a unique environment for the study of cancer from the molecular to the organismal level.

Duties
The applicant will be focused on designing and performing mass spectrometry (MS)-based studies focused on the molecular and cellular effects of anticancer compounds. Specifically, the applicant is expected to have well-documented experience with MS-based proteomics and phospho-proteomics, and cellular thermal shift assays (CETSA). This includes the preparation of MS samples from cell culture and tissue material, handling and working with LC-MS instrumentation (NanoMate, Orbitrap), and data processing and analysis using proteome databases. In addition, experience in protein-drug interaction studies using native mass spectrometry is a plus.

Entry requirements
The successful applicant holds a PhD in biochemistry, molecular biology, or pharmacology, with a strong track record in cancer-related drug development and mass spectrometry. They are expected to have a strong drive to pursue experimental research, and an ambitious and innovative attitude. The applicant will work closely with other members of the group, and good collaborative skills are necessary. Emphasis will be put on personal skills in the evaluation process. Very good ability to speak and write in English is a requirement.

Application process
An employment application must contain the following documents in English:

1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
2. A complete list of publications
3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.