Karolinska Institutet, Department of Neuroscience, Carlén

The Department of Neuroscience includes several research groups working on different aspects of nervous system function, both under normal conditions and in various disease states. Research projects include a broad range of studies on the molecular and cellular levels, networks of neurons, and the organization of the nervous system as a whole. The Department has a flat organization with 40 research group leaders, of which 24 are full professors, and 65 PhD students.

Teaching represents a fundamental activity at the Department, which participates in several undergraduate courses and postgraduate education programs. Each year approximately 15 students receive their PhD from our Department and many of our graduates have gone onto distinguished careers in the academic or private sector.

Dr Marie Carlén’s research group studies the neuronal underpinnings of cognition and goal-directed
behaviour. Cognition encompasses a range of mental abilities, including perception, attention, working memory, planning and decision making. Proper cognitive functions are thus essential for many aspects of our everyday life. Little is known about the computations underlying cognition, and the contribution of specific neuronal subtypes and brain areas. The Carlén lab is especially interested in the central role of the prefrontal cortex in cognition.

Division
Dr Marie Carlén research group studies how the brain codes and executes cognitive processes. Cognition encompasses a range of mental abilities, including perception, attention, working memory, planning and decision making. Proper cognitive functions are thus essential for many aspects of our everyday life. Little is known about how the brain's networks perform cognitive processes, including the role of different neuronal subtypes.

We are studying how different subtypes of neurons in prefrontal cortex interact, and how their activities contribute to computations underlying cognition. Currently, we are expanding our studies to include how brain areas interact with the prefrontal cortex to enable spatial and mental navigation. Our work aim to contribute to the understanding of how changes in the brain’s higher brain areas manifest as symptoms in neuropsychiatric disorders characterized by changed cognition.

Our studies utilize electrophysiological in vivo recordings, optogenetic manipulations and real-time imaging in behaving mice and rats. Apart from extensive utilization of in vivo technologies in behaving animals, we employ slice electrophysiology and viral tracing for deconstruction of local and long-range circuit connectivity.


Duties
We are looking for a highly motivated, experienced and independent person with documented expertise, and 1st author publications, in the field of systems neuroscience. Studies regarding the function of specific neuronal subtypes are particularly meriting.

Applicants are expected to have extensive experience of the following: Behavioral training of rodents; extra cellular electrophysiological recordings during behavior in rodents, including construction and building of tetrodes / microdrives and surgical implantation; intracranial injections of viral vectors; optogenetic manipulations of activity of selected neuronal cell types; perfusion and post hoc analysis of brain tissue; analysis of single, multi and LFP data, including programming skills (MatLab and more). Meriting is documented experience with optogenetics, as is experience of transgenic technologies (generation / characterization of transgenic mice or rats), and calcium imaging. Applicants must at the time of application hold approved education for work in mice and rats in accordance with European legislations.

Applicants should hold doctoral and/or postdoctoral experience and expertise of the above.


Entry requirements
Qualified to be employed as a postdoctor is the one who has obtained a doctorate or has equivalent scientific competence. A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

The employment is a temporary position, initially with 6 month's length with the possibility of extension for the right candidate.


Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Type of employment Special fixed-term employment
Contract type Full time
First day of employment As soon as possible
Salary Monthly salary
Number of positions 1
Full-time equivalent 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-3326/2018
Contact
  • Marie Carlén, Senior Researcher, marie.carlen@ki.se
Union representative
  • Anne Edgren, OFR/S, P, O, 08-524 87570
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 12.Jun.2018
Last application date 22.Jun.2018 11:59 PM CEST

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