Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Translational Medicine and Chemical Biology

The Bienko Laboratory for Quantitative Biology of the Nucleus (http://bienkocrosettolabs.org) at Karolinska Institutet (www.ki.se, ranked 9 in 2015-2016 QS) is located at SciLifeLab (www.scilifelab.se), an interdisciplinary center for biosciences bringing together researchers from four different universities and providing top-notch facility services to scientists all over Sweden. The Bienko Lab’s main goal is to unravel the fundamental design principles that govern the three-dimensional organization of the mammalian nucleus. To achieve this, the lab combines high-end microscopy techniques (DNA and RNA FISH) and next-generation sequencing methods (HiC, BLESS, in-house methods) with advanced mathematical tools (topological data analysis) in a thriving interdisciplinary atmosphere.

A position (postdoc level) is available for a DNA and RNA FISH platform manager that will be responsible for the following tasks: 1) construction and maintenance of a large database of probes for single-molecule RNA FISH (Raj et al., Nat Meth 2008), high-definition DNA FISH (Bienko et al, Nat Meth 2013), and other FISH methods that are being developed in the lab; 2) full management, including basic training of new users and maintenance of our custom-built fluorescence microscopy systems (Nikon Eclipse) used for high-resolution FISH measurements; 3) providing support with DNA and RNA FISH in the frame of collaborative projects.

Qualifications
The candidate should demonstrate a very strong background in both theory and practice of fluorescence microscopy (both wide-field and confocal microscopy), a solid expertise in basic molecular and cell biology methods (nucleic acid purification, PCR, cloning, cell culture), and preferably a record of work with DNA and/or RNA FISH methods. The ideal candidate should have a strong affinity for engineering aspects related to proper functioning and maintenance of microscopes (ability to troubleshoot) and a desire to provide top-quality FISH tools and expertise for multiple collaborative projects.

To apply
The application is to be registered in MyNetwork. Please attach motivation letter together with a complete CV, a full list of publications, and the contact details (name, institution, email) of two referees.

About scholarships
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Type of employment Postdoctoral studies.
Contract type Full time
Reference number 2-4204/2016
Contact
  • Magda Bienko , +46 (0)8-524 800 00
Union representative
  • Anne Edgren, OFR/S, P, O, +46 (0)8-616 16 29
  • Biborka Bereczky Veress, SACO, +46 (0)70-173 85 75
  • Henry Wölling, SEKO, +46 (0)8-524 840 80
Published 07.Nov.2016
Last application date 28.Nov.2016 11:59 PM CET

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