Postdoctoral studies in sex chromosome dosage compensation

Do you want to contribute to our understanding of fundamental gene regulation?

1-2 postdoc positions are available in the lab of Associate Professor Björn Reinius at the Department of Medical Biochemistry and Biophysics (MBB) at Karolinska Institutet. The Department is at the center of multi-disciplinary research that encompasses both basic and application-oriented research and offers a stimulating and dynamic research environment.

Our lab explores fundamental mechanisms of gene regulation, spanning sex and autosomal chromosome dosage compensation, genomic imprinting and gene regulatory mechanisms underpinning sex-biased differences in immune cell regulation.

Your mission

The Postdoctoral Fellow joining our team will investigate the molecular mechanisms of sex chromosome dosage compensation in model and non-model organisms. The project centers on exploring how dosage imbalances arising from the different number of sex chromosomes carried by females and males are corrected through sex chromosome dosage compensation. You will work with state-of-the-art next-generation sequencing-based approaches to dissect how gene regulation and dosage copensation are controlled at different regulatory layers, spanning chromatin accessibility and the chromatin landscape, allele-level transcriptional control and transcriptional kinetics as well as translational efficiency and protein abundances. Besides its focus on dosage compensation, the lab also works on method development in single-cell genomics. If there is mutual interest and a good match, there may be an opportunity for the postdoc to contribute also to such work.

Your profile

To be eligible for employment as a postdoctor, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

You are a creative, driven, and collaborative scientist with a PhD molecular biology, single-cell omics, sequencing-based methods and/or computational biology. You have a strong background in molecular and/or computational methods and documented hands-on experience with NGS methods such as single-cell RNA-seq, ATAC-seq, ChIP-seq, including sample preparation, data processing, and data interpretation. Experience with mouse embryo dissection, tissue collection, cell isolation and primary cell culture is a plus. Experience with automation of experimental procedures using Biomek or Tecan liquid handling systems is a further advantage.

You work independently while contributing effectively in a multidisciplinary team. You take initiative, show a strong sense of responsibility, and communicate clearly with colleagues from diverse scientific backgrounds. You have excellent written and spoken English skills and are an effective communicator in both presentations and scientific writing. Strong references from previous supervisors are expected.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

You will work in a creative, inspiring and vibrant research environment. You will be part of a research team that is dedicated to understanding fundamental and evolutionarily-conserved gene regulatory mechanisms implicated in both homeostasis and disease.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2025-12-28

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!