Postdoctoral studies in Spatial Single-Cell Proteomics of Metabolic Stress (scholarship)

Do you want to contribute to improving human health with novel technology?

Single-cell proteomics by mass spectrometry is an exciting and rapidly evolving research field. We elevate it to the spatial level through Deep Visual Proteomics (DVP), enabling us to analyse tissues with single-cell precision to track disease progression across both space and time. We want to understand the complex question of why metabolic diseases, especially mitochondrial defects, affect specific cell types differently. We seek exceptional postdoctoral fellows (one or two stipends available) passionate about developing and applying innovative technologies to human samples and model systems.

The Rosenberger lab

The Rosenberger lab is a young, diverse team of fewer than ten scientists passionate about cell biology. We develop and apply cutting-edge mass spectrometry-based proteomics to tackle complex biomedical questions. Our lab is equipped with an Orbitrap Astral, LMD7 laser microdissector, robotic sample prep, and strong computational infrastructure. You will work with samples from model systems and unique patient-derived tissues via our clinical collaborations, adding translational depth to your project. We offer an inclusive, mentorship-focused environment that supports career development, including fellowship and grant applications and, upon mutual interest, the possibility to transition to a salaried postdoctoral role.

The Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, is in the newly built Biomedicum at Solna campus. Our research encompasses both biochemical and genetic studies of patients with inherited diseases and basic approaches to understand mitochondrial metabolism. We work with patient materials, mouse and cell models, and fruit flies, offering close interaction between basic science and clinical diagnostics through the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital. Researchers have excellent access to advanced resources in molecular and cell biology at the department and through the national core facilities at Science for Life Laboratory.

For further details, please visit:

https://rosenbergerlab.org/

https://ki.se/en/mbb/research-division-of-molecular-metabolism

Your mission

Single-cell proteomics by mass spectrometry is an exciting and rapidly evolving research field. We elevate it to the spatial level through Deep Visual Proteomics (DVP), enabling us to analyse tissues with single-cell precision to track disease progression across both space and time. We want to understand the complex question of why metabolic diseases, especially mitochondrial defects, affect specific cell types differently. We seek exceptional postdoctoral fellows (one or two stipends available) passionate about developing and applying innovative technologies to human samples and model systems.

Your profile

We invite enthusiastic and motivated candidates with a PhD in molecular biology, any omics field, or bioinformatics to apply. You should embody our core values of creativity, collaboration, and effectiveness. Wet lab and/or bioinformatics experience is essential. Candidates with prior experience in omics (especially proteomics), metabolism, or mitochondrial research will receive favourable consideration. Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to work in a team to pursue their research. Personal suitability is of great importance when evaluating the applicants. Though not required, we strongly encourage and support applications for external postdoctoral fellowships. Please mention your interest in pursuing such opportunities in your cover letter.

Entry requirements

Postdoctoral scholarships may be established for foreign researchers who pursue their postdoctoral research in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location: Karolinska Institutet, Biomedicum, Solna, Sweden

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete resumé (max 3 pages)
• A complete list of publications
• A personal motivation letter, explaining your research interest (max 2 page)
• Contact information of at least two references

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all